School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Institute of Environmental Research at Greater Bay, Ministry of Education, Guangzhou University, Guangzhou 510006, China.
Molecules. 2021 Jun 14;26(12):3630. doi: 10.3390/molecules26123630.
It is crucial to establish relationship between nanoparticle structures (or properties) and nanotoxicity. Previous investigations have shown that a nanoparticle's size, shape, surface and core materials all impact its toxicity. However, the relationship between the redox property of nanoparticles and their toxicity has not been established when all other nanoparticle properties are identical. Here, by synthesizing an 80-membered combinatorial gold nanoparticle (GNP) library with diverse redox properties, we systematically explored this causal relationship. The compelling results revealed that the oxidative reactivity of GNPs, rather than their other physicochemical properties, directly caused cytotoxicity via induction of cellular oxidative stress. Our results show that the redox diversity of nanoparticles is regulated by GNPs modified with redox reactive ligands.
确定纳米颗粒结构（或性质）与纳米毒性之间的关系至关重要。先前的研究表明，纳米颗粒的大小、形状、表面和核心材料都会影响其毒性。然而，当所有其他纳米颗粒性质相同时，纳米颗粒的氧化还原性质与其毒性之间的关系尚未建立。在这里，我们通过合成具有不同氧化还原性质的 80 成员组合金纳米颗粒（GNP）文库，系统地探索了这种因果关系。令人信服的结果表明，GNP 的氧化反应性，而不是其他物理化学性质，通过诱导细胞氧化应激直接导致细胞毒性。我们的结果表明，纳米颗粒的氧化还原多样性受 GNP 与氧化还原反应性配体的修饰所调控。
