功能化金纳米颗粒及其生物医学应用。

Tiwari Pooja M, Vig Komal, Dennis Vida A, Singh Shree R

Center for NanoBiotechnology Research, Alabama State University, 1627, Hall Street, Montgomery, AL 36101, USA.

Nanomaterials (Basel). 2011 Jun 14;1(1):31-63. doi: 10.3390/nano1010031.

Metal nanoparticles are being extensively used in various biomedical applications due to their small size to volume ratio and extensive thermal stability. Gold nanoparticles (GNPs) are an obvious choice due to their amenability of synthesis and functionalization, less toxicity and ease of detection. The present review focuses on various methods of functionalization of GNPs and their applications in biomedical research. Functionalization facilitates targeted delivery of these nanoparticles to various cell types, bioimaging, gene delivery, drug delivery and other therapeutic and diagnostic applications. This review is an amalgamation of recent advances in the field of functionalization of gold nanoparticles and their potential applications in the field of medicine and biology.

由于金属纳米颗粒的小尺寸体积比和广泛的热稳定性，它们正在被广泛应用于各种生物医学领域。金纳米颗粒（GNPs）因其易于合成和功能化、低毒性以及易于检测，成为了一个明显的选择。本综述聚焦于金纳米颗粒的各种功能化方法及其在生物医学研究中的应用。功能化有助于将这些纳米颗粒靶向递送至各种细胞类型，应用于生物成像、基因递送、药物递送以及其他治疗和诊断应用。这篇综述融合了金纳米颗粒功能化领域的最新进展及其在医学和生物学领域的潜在应用。