Côté Héloïse, Pichette André, St-Gelais Alexis, Legault Jean
Laboratoire d'Analyse et de Séparation des Essences Végétales, Université du Québec à Chicoutimi, 555 boulevard de l'Université, Chicoutimi, QC G7H 2B1, Canada.
Centre de Recherche sur la Boréalie (CREB), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, 555 boulevard de l'Université, Chicoutimi, QC G7H 2B1, Canada.
Molecules. 2021 Jun 2;26(11):3368. doi: 10.3390/molecules26113368.
The use of growth-promoting antibiotics in livestock faces increasing scrutiny and opposition due to concerns about the increased occurrence of antibiotic-resistant bacteria. Alternative solutions are being sought, and plants of Lamiaceae may provide an alternative to synthetic antibiotics in animal nutrition. In this study, we extracted essential oil from , a member of the Lamiaceae family. We examined the chemical composition of the essential oil and then evaluated the antibacterial, antioxidant, and anti-inflammatory activities of essential oil and its main compounds . We then evaluated the effectiveness of essential oil in regard to growth performance, feed efficiency, and mortality in both mice and broilers. Carvacrol (49.03%) was the dominant compound in the essential oil extracts. essential oil demonstrated antibacterial properties against (MIC = 87 µg·mL), (MIC = 47 µg·mL), and (MIC = 35 µg·mL). Supplementing the diet of mice with essential oil at a concentration of 0.1% significantly increased body weight (+5.4%) and feed efficiency (+18.85%). In broilers, essential oil significantly improved body weight gain (2.64%). Our results suggest that adding essential oil to the diet of broilers offers a potential substitute for antibiotic growth promoters.
由于担心抗生素耐药菌的出现增加，在牲畜中使用促生长抗生素面临越来越多的审查和反对。人们正在寻找替代解决方案，唇形科植物可能为动物营养中的合成抗生素提供一种替代品。在本研究中，我们从唇形科植物中提取了精油。我们检查了精油的化学成分，然后评估了精油及其主要化合物的抗菌、抗氧化和抗炎活性。然后，我们评估了精油在小鼠和肉鸡的生长性能、饲料效率和死亡率方面的有效性。香芹酚（49.03%）是精油提取物中的主要化合物。精油对（最低抑菌浓度=87微克·毫升）、（最低抑菌浓度=47微克·毫升）和（最低抑菌浓度=35微克·毫升）具有抗菌特性。以0.1%的浓度在小鼠饮食中添加精油显著增加了体重（+5.4%）和饲料效率（+18.85%）。在肉鸡中，精油显著提高了体重增加（2.64%）。我们的结果表明，在肉鸡饮食中添加精油为抗生素生长促进剂提供了一种潜在的替代品。
