Kiluk Małgorzata, Lewkowicz Janina, Pawlak Dariusz, Tankiewicz-Kwedlo Anna
Department of Internal Medicine and Metabolic Diseases, Medical University of Bialystok, 15-089 Białystok, Poland.
Department of Pharmacodynamics, Medical University of Bialystok, 15-089 Białystok, Poland.
J Clin Med. 2021 Jun 4;10(11):2484. doi: 10.3390/jcm10112484.
Scientific interest in tryptophan metabolism via the kynurenine pathway (KP) has increased in the last decades. Describing its metabolites helped to increase their roles in many diseases and disturbances, many of a pro-inflammatory nature. It has become increasingly evident that KP can be considered an important part of emerging mediators of diabetes mellitus and metabolic syndrome (MS), mostly stemming from chronic systemic low-grade inflammation resulting in the aggravation of cardiovascular complications. An electronic literature search of PubMed and Embase up to March 2021 was performed for papers reporting the effects of tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYNA), xanthurenic acid (XA), anthranilic acid (AA), and quinolinic acid (QA), focusing on their roles in carbohydrate metabolism and the cardiovascular system. In this review, we discussed the progress in tryptophan metabolism via KP research, focusing particular attention on the roles in carbohydrate metabolism and its complications in the cardiovascular system. We examined the association between KP and diabetes mellitus type 2 (T2D), diabetes mellitus type 1 (T1D), and cardiovascular diseases (CVD). We concluded that tryptophan metabolism via KP serves as a potential diagnostic tool in assessing cardiometabolic risk for patients with T2D.
在过去几十年中，科学界对通过犬尿氨酸途径（KP）进行的色氨酸代谢的兴趣有所增加。对其代谢产物的描述有助于提升它们在许多疾病和紊乱中的作用，其中许多具有促炎性质。越来越明显的是，KP可被视为糖尿病和代谢综合征（MS）新出现的介质的重要组成部分，这些介质大多源于慢性全身性低度炎症，导致心血管并发症加重。截至2021年3月，我们在PubMed和Embase上进行了电子文献检索，以查找报告色氨酸（TRP）、犬尿氨酸（KYN）、犬尿喹啉酸（KYNA）、黄尿酸（XA）、邻氨基苯甲酸（AA）和喹啉酸（QA）作用的论文，重点关注它们在碳水化合物代谢和心血管系统中的作用。在本综述中，我们讨论了通过KP研究色氨酸代谢的进展，特别关注其在碳水化合物代谢中的作用及其在心血管系统中的并发症。我们研究了KP与2型糖尿病（T2D）、1型糖尿病（T1D）和心血管疾病（CVD）之间的关联。我们得出结论，通过KP进行的色氨酸代谢可作为评估T2D患者心脏代谢风险的潜在诊断工具。
