Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, Epidemiology Group, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Medicina (Kaunas). 2021 Jun 7;57(6):585. doi: 10.3390/medicina57060585.
: In this paper, we investigated the efficacy of statin therapy on cardiovascular disease (CVD) reduction in adults with no known underlying health conditions by undertaking a meta-analysis and systematic review of the current evidence. : We performed a systematic search to identify Primary Prevention Randomized Controlled Trials (RCTs) that compared statins with a control group where CVD events or mortality were the primary end point. Identified RCTs were evaluated and classified into categories depending on relevance in order to determine which type of meta-analysis would be feasible. : No differences were observed between categories with the exception of relative risk for all CVD events combined which showed a 12% statistically significant difference favouring studies which were known to include participants without underlying health conditions. Strong negative correlations between number-need-to-treat (NNT) and LDL-C reduction were observed for all Coronary Heart Disease (CHD) outcomes combined and all CVD outcomes combined. : This project highlights the need for further research on the effects of statins on participants who do not suffer from underlying health conditions, given that no such studies have been conducted.
: 在这项研究中，我们通过对现有证据进行荟萃分析和系统评价，研究了他汀类药物治疗对无潜在健康状况的成年人心血管疾病（CVD）减少的效果。: 我们进行了系统搜索，以确定将他汀类药物与以 CVD 事件或死亡率为主要终点的对照组进行比较的一级预防随机对照试验（RCT）。评估了确定的 RCT 并根据相关性进行分类，以确定哪种类型的荟萃分析是可行的。: 除了所有 CVD 事件的相对风险显示出统计学上有 12%的显著差异，有利于已知包括无潜在健康状况的参与者的研究外，类别之间没有观察到差异。所有冠心病（CHD）结局和所有 CVD 结局的联合观察到，数量需要治疗（NNT）和 LDL-C 降低之间存在强烈的负相关。: 鉴于没有进行此类研究，本项目强调了需要进一步研究他汀类药物对无潜在健康状况的参与者的影响。
