Zoppo Marina, Poma Noemi, Di Luca Mariagrazia, Bottai Daria, Tavanti Arianna
Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland.
Department of Chemistry and Industrial Chemistry, University of Pisa, 56127 Pisa, Italy.
J Fungi (Basel). 2021 Jun 7;7(6):459. doi: 10.3390/jof7060459.
An increase in the rate of isolation of in the past decade, as well as increased identification of azole-resistant strains are concerning, and require better understanding of virulence-like factors and drug-resistant traits of these species. In this regard, the present review "draws a line" on the information acquired, thus far, on virulence determinants and molecular mechanisms of antifungal resistance in these opportunistic pathogens, mainly derived from genetic manipulation studies. This will provide better focus on where we stand in our understanding of the species complex-host interaction, and how far we are from defining potential novel targets or therapeutic strategies-key factors to pave the way for a more tailored management of fungal infections caused by these fungal pathogens.
在过去十年中，[具体真菌名称]的分离率有所上升，同时对唑类耐药菌株的鉴定也有所增加，这令人担忧，需要更好地了解这些菌种的毒力样因子和耐药特性。在这方面，本综述梳理了迄今为止在这些机会性病原体中获得的关于毒力决定因素和抗真菌耐药分子机制的信息，这些信息主要来自基因操作研究。这将使我们更清楚地了解我们对[具体真菌名称]菌种复合体与宿主相互作用的理解程度，以及我们距离确定潜在的新靶点或治疗策略还有多远，而这些是为更有针对性地管理由这些真菌病原体引起的真菌感染铺平道路的关键因素。
