Franconi Iacopo, Rizzato Cosmeri, Poma Noemi, Tavanti Arianna, Lupetti Antonella
Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Via San Zeno, 37, 56127 Pisa, Italy.
Department of Biology, University of Pisa, Via San Zeno, 37, 56127 Pisa, Italy.
J Fungi (Basel). 2023 Jul 28;9(8):798. doi: 10.3390/jof9080798.
Fungal diseases cause millions of deaths per year worldwide. Antifungal resistance has become a matter of great concern in public health. In recent years rates of non- species have risen dramatically. is now reported to be the second most frequent species causing candidemia in several countries in Europe, Latin America, South Africa and Asia. Rates of acquired azole resistance are reaching a worrisome threshold from multiple reports as in vitro susceptibility testing is now starting also to explore tolerance and heteroresistance to antifungal compounds. With this review, the authors seek to evaluate known antifungal resistance mechanisms and their worldwide distribution in species infections with a specific focus on .
真菌病每年在全球导致数百万人死亡。抗真菌药物耐药性已成为公共卫生领域极为关注的问题。近年来，非[具体物种]的发生率急剧上升。据报道，在欧洲、拉丁美洲、南非和亚洲的几个国家，[具体物种]现已成为引起念珠菌血症的第二常见物种。从多份报告来看，获得性唑类耐药率正达到令人担忧的阈值，因为体外药敏试验现在也开始探索对抗真菌化合物的耐受性和异质性耐药。通过本综述，作者试图评估已知的抗真菌耐药机制及其在[具体物种]感染中的全球分布情况，并特别关注[具体物种]。
