新型双氯芬酸与精油组合对不同菌种的协同活性
Synergistic Activity of New Diclofenac and Essential Oils Combinations against Different spp.
作者信息
Rosato Antonio, Altini Elisabetta, Sblano Sabina, Salvagno Lara, Maggi Filippo, de Michele Giuliana, Carocci Alessia, Clodoveo Maria Lisa, Corbo Filomena, Fracchiolla Giuseppe
机构信息
Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy.
School of Pharmacy, University of Camerino, 62032 Camerino, Italy.
出版信息
Antibiotics (Basel). 2021 Jun 8;10(6):688. doi: 10.3390/antibiotics10060688.
According to recent studies, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) have shown a good antimicrobial and antifungal activity. Their association with essential oils (EOs) could be useful for the treatment of infections caused by . The aim of this studyis to evaluate the synergistic antifungal activity of new combinations between Diclofenac Sodium Salt (DSS), a widely used NSAID, with EOs of , and . The in-vitro antifungal activity was determined on different strains. The determination of the chemical composition of EOs was carried out by gaschromatography-massspectrometry (GC-MS). Susceptibility testing of planktonic cells was performed by using the broth microdilution assay and checkerboard methods. Minimum Inhibitory Concentrations (MIC) of DSS was in a range from 1.02 to 2.05 μg/mL reaching a MIC value of 0.05 μg/mL when combined with (FICI = 0.23-0.35) or (FICI = 0.22-0.30) EOs. These preliminary results show thatthe combination of the EOs with DSS improves the antifungal activity on all the tested strains.
根据最近的研究，非甾体抗炎药（NSAIDs）已显示出良好的抗菌和抗真菌活性。它们与精油（EOs）联合使用可能有助于治疗由……引起的感染。本研究的目的是评估广泛使用的非甾体抗炎药双氯芬酸钠盐（DSS）与……、……和……的精油之间新组合的协同抗真菌活性。在不同的……菌株上测定了体外抗真菌活性。通过气相色谱-质谱联用（GC-MS）对精油的化学成分进行了测定。采用肉汤微量稀释法和棋盘法对浮游细胞进行药敏试验。DSS的最低抑菌浓度（MIC）在1.02至2.05μg/mL范围内，与……（FICI = 0.23 - 0.35）或……（FICI = 0.22 - 0.30）精油联合使用时，MIC值达到0.05μg/mL。这些初步结果表明，精油与DSS的组合提高了对所有测试的……菌株的抗真菌活性。
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