精油作为氟康唑抗真菌活性的有效增强剂对.

Essential Oils as Effective Enhancers of Fluconazole Antifungal Activity against .

机构信息

Faculty of Biotechnology and Animal Husbandry, Department of Monogastric Animal Sciences, West Pomeranian University of Technology in Szczecin, Janickiego Str. 29, 71-270 Szczecin, Poland.

Faculty of Chemical Technology and Engineering, Department of Chemical Organic Technology and Polymeric Materials, West Pomeranian University of Technology in Szczecin, Piastów Ave. 42, 71-065 Szczecin, Poland.

出版信息

Molecules. 2023 Jan 25;28(3):1176. doi: 10.3390/molecules28031176.

DOI:10.3390/molecules28031176

PMID:36770842

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9921790/

Abstract

The increasing prevalence of resistance to commercial antifungal agents in recent decades has prompted modern medicine and veterinary medicine to search for combined treatment options. The aim of the study was to determine the activity of essential oils from different cultivars and morphological parts of the medicinal lavender () in combination with fluconazole against ATCC 10231 strain. The effect of the combination of lavender essential oil with fluconazole was tested using the checkerboard method, and the obtained results were interpreted on the basis of fractional inhibitory concentration indices (FICIs). A synergistic interaction was found for all combinations of fluconazole with essential oils isolated both from flowers and leafy stalks of two tested lavender cultivars: 'Blue River' and 'Ellagance Purple'. The observed enhancement effect of fluconazole antifungal activity was significantly stronger in the case of essential oils obtained from flowers and leafy stalks of 'Blue River' cultivar. Analogous studies were performed for linalool, one of the main components of lavender essential oils, and a similar synergistic interaction with fluconazole was found.

摘要

近几十年来，商业抗真菌药物耐药性的日益流行促使现代医学和兽医学寻求联合治疗方案。本研究旨在确定不同品种和药用薰衣草（）形态部位精油与氟康唑联合使用对 ATCC 10231 菌株的活性。使用棋盘法测试薰衣草精油与氟康唑联合使用的效果，并根据部分抑菌浓度指数（FICI）解释获得的结果。发现氟康唑与从两种测试薰衣草品种（“蓝河”和“埃拉根斯紫”）的花朵和叶状茎中分离的精油的所有组合均具有协同相互作用。从“蓝河”薰衣草品种的花朵和叶状茎中获得的精油增强氟康唑抗真菌活性的效果更为明显。对薰衣草精油的主要成分之一芳樟醇也进行了类似的研究，发现其与氟康唑具有类似的协同作用。