Department of Neurology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Oleander Medical Technologies, Baton Rouge, LA 70803, USA.
Curr Oncol. 2021 Jun 8;28(3):2115-2122. doi: 10.3390/curroncol28030196.
Upregulation of voltage-gated sodium channels (VGSCs) and Na/K-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological blockade of sodium pumps causes rapid selective osmotic lysis of carcinoma cells. This treatment of cervical carcinoma is evidence that TOL is a safe, well-tolerated and effective treatment for aggressive advanced carcinomas that has the potential to extend life without compromising its quality. TOL is likely to have broad application for the treatment of advanced-stage carcinomas.
电压门控钠离子通道（VGSCs）和 Na/K-ATP 酶（钠泵）的上调在大多数恶性癌中都很常见。靶向渗透性溶解（TOL）是一种正在发展中的技术，它同时刺激 VGSCs 并抑制钠泵，导致癌细胞快速选择性渗透性溶解。这种宫颈癌的治疗方法表明，TOL 是一种安全、耐受良好且有效的治疗侵袭性晚期癌的方法，有可能延长生命而不降低其质量。TOL 很可能有广泛的应用于治疗晚期癌症。
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