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靶向渗透溶解在伴侣动物晚期癌治疗中的作用：病例系列

The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series.

作者信息

Gould Harry J, Edenfield Samantha, Miller Paige R, Sherman Kelly Jean, Melius Brian, Whitney Alissa, Hunter Robert P, Del Piero Fabio, Tracey Dennis, Paul Dennis

机构信息

Department of Neurology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Oleander Medical Technologies, Baton Rouge and New Orleans, LA, USA.

出版信息

Case Rep Vet Med. 2022 Aug 2;2022:2747108. doi: 10.1155/2022/2747108. eCollection 2022.

DOI:10.1155/2022/2747108
PMID:35967596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9363929/
Abstract

BACKGROUND

Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na, K-ATPase causing lysis of highly malignant cancer cells. . TOL offers an option for treating advanced carcinomas in companion animals. . Two cats and 2 dogs that presented to veterinary hospitals for evaluation and treatment of one of several forms of carcinoma.

METHODS

Digoxin was administered to achieve steady-state, therapeutic concentrations. The animals were then exposed to pulsed electric field stimulation. Pre- and posttreatment assessments of tumor size and quality of life were compared. The treatment frequency and survivability varied, based on the patient's premorbid functioning and response to treatment.

RESULTS

Regardless of cancer type, TOL consistently increased survival beyond expected, often improving, but without compromising of quality of life. . TOL warrants consideration as an option for managing advanced carcinomas.

摘要

背景

靶向渗透裂解（TOL）是一种新技术，涉及同时刺激电压门控钠通道（VGSCs）和对钠钾ATP酶进行药理学阻断，从而导致高度恶性癌细胞裂解。TOL为治疗伴侣动物的晚期癌症提供了一种选择。两只猫和两只狗因几种形式的癌症之一到兽医医院进行评估和治疗。

方法

给予地高辛以达到稳态治疗浓度。然后对动物进行脉冲电场刺激。比较治疗前后肿瘤大小和生活质量的评估。治疗频率和生存率因患者病前功能和对治疗的反应而异。

结果

无论癌症类型如何，TOL始终能使生存期超出预期，通常有所改善，且不影响生活质量。TOL值得作为治疗晚期癌症的一种选择加以考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a05/9363929/679a07eeff99/CRIVEM2022-2747108.013.jpg
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