Rizk Soha S, Elwakil Wafaa H, Attia Ahmed S
Microbiology and Immunology Postgraduate Program, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Antibiotics (Basel). 2021 Jun 23;10(7):764. doi: 10.3390/antibiotics10070764.
is an emerging pathogen, and over the last three decades it has proven to be particularly difficult to treat by healthcare services. It is now regarded as a formidable infectious agent with a genetic setup for prompt development of resistance to most of the available antimicrobial agents. Yet, it is noticed that there is a gap in the literature covering this pathogen especially in countries with limited resources. In this review, we provide a comprehensive updated overview of the available data about , the multi-drug resistant (MDR) phenotype spread, carbapenem-resistance, and the associated genetic resistance determinants in low-income countries (LIICs) since the beginning of the 21st century. The coverage included three major databases; PubMed, Scopus, and Web of Science. Only 52 studies were found to be relevant covering only 18 out of the 29 countries included in the LIC group. Studies about two countries, Syria and Ethiopia, contributed ~40% of the studies. Overall, the survey revealed a wide spread of MDR and alarming carbapenem-resistance profiles. Yet, the total number of studies is still very low compared to those reported about countries with larger economies. Accordingly, a discussion about possible reasons and recommendations to address the issue is presented. In conclusion, our analyses indicated that the reported studies of in the LICs is far below the expected numbers based on the prevailing circumstances in these countries. Lack of proper surveillance systems due to inadequate financial resources could be a major contributor to these findings.
是一种新兴病原体，在过去三十年中，医疗服务机构已证明其特别难以治疗。它现在被视为一种强大的传染因子，其基因构成使其能迅速对大多数现有抗菌药物产生耐药性。然而，人们注意到，尤其是在资源有限的国家，关于这种病原体的文献存在空白。在本综述中，我们全面更新了自21世纪初以来低收入国家（LICs）中关于该病原体、多重耐药（MDR）表型传播、碳青霉烯耐药性以及相关基因耐药决定因素的可用数据概述。涵盖的数据库有三个主要的；即PubMed、Scopus和科学网。仅发现52项研究相关，仅涵盖LIC组29个国家中的18个国家。关于叙利亚和埃塞俄比亚这两个国家的研究占研究总数的约40%。总体而言，调查显示MDR广泛传播且碳青霉烯耐药情况令人担忧。然而，与经济规模较大国家报告的研究相比，研究总数仍然非常少。因此，本文讨论了可能的原因以及解决该问题的建议。总之，我们的分析表明，LICs中关于该病原体的报告研究远低于基于这些国家普遍情况预期的数量。由于财政资源不足导致缺乏适当的监测系统可能是造成这些结果的主要原因。
