College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Molecules. 2021 Jun 25;26(13):3883. doi: 10.3390/molecules26133883.
Eight novel pyridyl-oxazole carboxamides were evaluated against fungi and displayed good fungicidal activities against and . Preliminary bioassay results indicated that at 100 mg/L, compounds -, and exhibited 100% fungicidal activities against , and the compound to at 100%. Then, the zebrafish embryo acute toxicity test was performed to assess the toxicity of and . A series of malformations appeared, when the zebrafish embryos were exposed to and , such as delayed yolk sac resorption, significant shortening of body length, pericardial edema, bending spine, lack of melanin, heart hemorrhage, head hemorrhage, delayed swim sac development, yolk malformation and head malformation. In addition, the acute toxicity of to zebrafish embryo is 4.878 mg/L, and is 6.257 mg/L.
八种新型吡啶-噁唑甲酰胺类化合物进行了抗真菌活性评估，对 和 显示出良好的杀菌活性。初步生物测定结果表明，在 100mg/L 时，化合物 - 、 和 对 显示出 100%的杀菌活性，化合物 对 的抑制率为 100%。然后，进行了斑马鱼胚胎急性毒性试验来评估 和 的毒性。当斑马鱼胚胎暴露于 和 时，出现了一系列畸形，如卵黄囊吸收延迟、体长显著缩短、心包水肿、脊柱弯曲、黑色素缺乏、心脏出血、头部出血、游泳囊发育延迟、卵黄畸形和头部畸形。此外，化合物 对斑马鱼胚胎的急性毒性为 4.878mg/L，化合物 对斑马鱼胚胎的急性毒性为 6.257mg/L。
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