Zhu Chaojie, Ji Zhiheng, Ma Junkai, Ding Zhijie, Shen Jie, Wang Qiwen
Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Chu Kochen Honors College of Zhejiang University, Hangzhou 310058, China.
Pharmaceutics. 2021 Jun 24;13(7):940. doi: 10.3390/pharmaceutics13070940.
Cancer is one of the most devastating and ubiquitous human diseases. Conventional therapies like chemotherapy and radiotherapy are the most widely used cancer treatments. Despite the notable therapeutic improvements that these measures achieve, disappointing therapeutic outcome and cancer reoccurrence commonly following these therapies demonstrate the need for better alternatives. Among them, bacterial therapy has proven to be effective in its intrinsic cancer targeting ability and various therapeutic mechanisms that can be further bolstered by nanotechnology. In this review, we will discuss recent advances of nanotechnology-facilitated bacteria-based drug and gene delivery systems in cancer treatment. Therapeutic mechanisms of these hybrid nanoformulations are highlighted to provide an up-to-date understanding of this emerging field.
癌症是最具毁灭性且普遍存在的人类疾病之一。化疗和放疗等传统疗法是使用最广泛的癌症治疗方法。尽管这些措施取得了显著的治疗进展，但这些疗法之后常见的令人失望的治疗结果和癌症复发表明需要更好的替代方案。其中，细菌疗法已被证明在其内在的癌症靶向能力以及可通过纳米技术进一步增强的各种治疗机制方面是有效的。在本综述中，我们将讨论纳米技术促进的基于细菌的药物和基因递送系统在癌症治疗中的最新进展。强调了这些混合纳米制剂的治疗机制，以提供对这一新兴领域的最新理解。
