School of Biological and Biomedical Sciences, Galgotias University, Greater Noida, India.
Department of Pharmaceutics, Galgotias University, Greater Noida, India.
Crit Rev Ther Drug Carrier Syst. 2021;38(6):1-48. doi: 10.1615/CritRevTherDrugCarrierSyst.2021036437.
Oral cancer is the 11th most common cancer in the world with a high morbidity rate. Various conventional therapies have been used for the treatment of oral cancer such as surgery, radiotherapy, and chemotherapy used either alone or in combination but these have many limitations, making them unsuitable for treating oral cancer. Nanotechnology has been emerged out as an innovative tool in the field of oral cancer which has proved to provide effective results overcoming the limitations of conventional drug therapies. This system involves a nanoparticle drug delivery system based on a targeted therapy in which therapeutic drugs or agents act on the targeted cells without affecting normal healthy cells. Literature has shown that several nanoparticles, organic and inorganic nanoparticles, have been used as the drug delivery system in different types of oral cancers such as oral squamous cell carcinoma, cancer of the tongue, head, and neck cancers. Drugs like cisplatin, 5-fluorouracil, methotrexate, doxorubicin, etc., when coated with nano-polymers have shown better results compared with conventional drugs in oral cancer. Other nanoparticles such as liposomes, hydrogels, nanodiamonds, carbon rods, etc. have also been used with minimal side effects. This paper aims to review and discuss various nanotechnology systems in the field of oral cancer and to evaluate the efficacy of these systems in treating oral cancer compared with conventional drug delivery methods.
口腔癌是全球第 11 大常见癌症，发病率较高。各种传统疗法已被用于治疗口腔癌，如手术、放疗和化疗，这些疗法单独或联合使用，但都有许多局限性，不适合治疗口腔癌。纳米技术已成为口腔癌领域的一种创新工具，事实证明，它克服了传统药物治疗的局限性，提供了有效的治疗效果。该系统涉及一种基于靶向治疗的纳米药物传递系统，其中治疗药物或试剂作用于靶向细胞而不影响正常健康细胞。文献表明，几种纳米颗粒，包括有机和无机纳米颗粒，已被用作不同类型口腔癌（如口腔鳞状细胞癌、舌癌、头颈部癌症）的药物传递系统。与传统药物相比，用纳米聚合物包裹的顺铂、5-氟尿嘧啶、甲氨蝶呤、阿霉素等药物在口腔癌治疗中显示出更好的效果。其他纳米颗粒，如脂质体、水凝胶、纳米金刚石、碳棒等，也具有较小的副作用。本文旨在综述和讨论口腔癌领域的各种纳米技术系统，并评估这些系统与传统药物输送方法相比在治疗口腔癌方面的疗效。
