新型聚（酯氨酯脲）/聚二恶烷酮共混物：静电纺纤维网和膜。
Novel Poly(ester urethane urea)/Polydioxanone Blends: Electrospun Fibrous Meshes and Films.
机构信息
Department of Physics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Center for Nanoscale Materials and Biointegration (CNMB), University of Alabama at Birmingham, Birmingham, AL 35294, USA.
出版信息
Molecules. 2021 Jun 24;26(13):3847. doi: 10.3390/molecules26133847.
In this work, we report the electrospinning and mechano-morphological characterizations of scaffolds based on blends of a novel poly(ester urethane urea) (PHH) and poly(dioxanone) (PDO). At the optimized electrospinning conditions, PHH, PDO and blend PHH/PDO in Hexafluroisopropanol (HFIP) solution yielded bead-free non-woven random nanofibers with high porosity and diameter in the range of hundreds of nanometers. The structural, morphological, and biomechanical properties were investigated using Differential Scanning Calorimetry, Scanning Electron Microscopy, Atomic Force Microscopy, and tensile tests. The blended scaffold showed an elastic modulus (~5 MPa) with a combination of the ultimate tensile strength (2 ± 0.5 MPa), and maximum elongation (150% ± 44%) in hydrated conditions, which are comparable to the materials currently being used for soft tissue applications such as skin, native arteries, and cardiac muscles applications. This demonstrates the feasibility of an electrospun PHH/PDO blend for cardiac patches or vascular graft applications that mimic the nanoscale structure and mechanical properties of native tissue.
在这项工作中，我们报告了基于新型聚酯氨酯脲（PHH）和聚（二氧杂环己酮）（PDO）共混物的支架的静电纺丝和力学形态特征。在优化的静电纺丝条件下，PHH、PDO 和 PHH/PDO 共混物在六氟异丙醇（HFIP）溶液中生成了具有高孔隙率和数百纳米范围内直径的无珠无纺随机纳米纤维。使用差示扫描量热法、扫描电子显微镜、原子力显微镜和拉伸试验研究了结构、形态和生物力学性能。混合支架在水合条件下表现出弹性模量（~5 MPa），结合了极限拉伸强度（2±0.5 MPa）和最大伸长率（150%±44%），这与目前用于软组织应用（如皮肤、天然动脉和心肌应用）的材料相当。这证明了静电纺丝 PHH/PDO 共混物用于心脏补片或血管移植物的可行性，这些应用可以模拟天然组织的纳米结构和力学性能。
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