预处理和归一化方法对脑MRI影像组学特征中扫描仪效应去除的影响
Impact of Preprocessing and Harmonization Methods on the Removal of Scanner Effects in Brain MRI Radiomic Features.
作者信息
Li Yingping, Ammari Samy, Balleyguier Corinne, Lassau Nathalie, Chouzenoux Emilie
机构信息
Laboratoire d'Imagerie Biomédicale Multimodale Paris Saclay, UMR1281 Inserm, Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), Centre National de la Recherche Scientifique, Université Paris-Saclay, 94805 Villejuif, France.
Centre de Vision Numérique, Institut National de Recherche en Informatique et en Automatique (INRIA), Université Paris-Saclay, 91190 Gif-sur-Yvette, France.
出版信息
Cancers (Basel). 2021 Jun 15;13(12):3000. doi: 10.3390/cancers13123000.
In brain MRI radiomics studies, the non-biological variations introduced by different image acquisition settings, namely scanner effects, affect the reliability and reproducibility of the radiomics results. This paper assesses how the preprocessing methods (including N4 bias field correction and image resampling) and the harmonization methods (either the six intensity normalization methods working on brain MRI images or the ComBat method working on radiomic features) help to remove the scanner effects and improve the radiomic feature reproducibility in brain MRI radiomics. The analyses were based on in vitro datasets (homogeneous and heterogeneous phantom data) and in vivo datasets (brain MRI images collected from healthy volunteers and clinical patients with brain tumors). The results show that the ComBat method is essential and vital to remove scanner effects in brain MRI radiomic studies. Moreover, the intensity normalization methods, while not able to remove scanner effects at the radiomic feature level, still yield more comparable MRI images and improve the robustness of the harmonized features to the choice among ComBat implementations.
在脑磁共振成像(MRI)的放射组学研究中,不同图像采集设置所引入的非生物学变异,即扫描仪效应,会影响放射组学结果的可靠性和可重复性。本文评估了预处理方法(包括N4偏置场校正和图像重采样)以及归一化方法(作用于脑MRI图像的六种强度归一化方法或作用于放射组学特征的ComBat方法)如何有助于消除扫描仪效应,并提高脑MRI放射组学中放射组学特征的可重复性。分析基于体外数据集(均匀和异质体模数据)和体内数据集(从健康志愿者和患有脑肿瘤的临床患者收集的脑MRI图像)。结果表明,ComBat方法对于消除脑MRI放射组学研究中的扫描仪效应至关重要。此外,强度归一化方法虽然无法在放射组学特征层面消除扫描仪效应,但仍能生成更具可比性的MRI图像,并提高归一化特征在ComBat实现方案选择中的稳健性。
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