Ammari Samy, Pitre-Champagnat Stephanie, Dercle Laurent, Chouzenoux Emilie, Moalla Salma, Reuze Sylvain, Talbot Hugues, Mokoyoko Tite, Hadchiti Joya, Diffetocq Sebastien, Volk Andreas, El Haik Mickeal, Lakiss Sara, Balleyguier Corinne, Lassau Nathalie, Bidault Francois
Department of Radiology, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France.
BioMaps (UMR1281), Université Paris-Saclay, CNRS, INSERM, CEA, Orsay and Gustave Roussy, Villejuif, France.
Front Oncol. 2021 Jan 20;10:541663. doi: 10.3389/fonc.2020.541663. eCollection 2020.
The development and clinical adoption of quantitative imaging biomarkers (radiomics) has established the need for the identification of parameters altering radiomics reproducibility. The aim of this study was to assess the impact of magnetic field strength on magnetic resonance imaging (MRI) radiomics features in neuroradiology clinical practice.
T1 3D SPGR sequence was acquired on two phantoms and 10 healthy volunteers with two clinical MR devices from the same manufacturer using two different magnetic fields (1.5 and 3T). Phantoms varied in terms of gadolinium concentrations and textural heterogeneity. 27 regions of interest were segmented (phantom: 21, volunteers: 6) using the LIFEX software. 34 features were analyzed.
In the phantom dataset, 10 (67%) out of 15 radiomics features were significantly different when measured at 1.5T or 3T (student's t-test, p < 0.05). Gray levels resampling, and pixel size also influence part of texture features. These findings were validated in healthy volunteers.
According to daily used protocols for clinical examinations, radiomic features extracted on 1.5T should not be used interchangeably with 3T when evaluating texture features. Such confounding factor should be adjusted when adapting the results of a study to a different platform, or when designing a multicentric trial.
定量成像生物标志物（放射组学）的发展和临床应用使得识别影响放射组学可重复性的参数成为必要。本研究的目的是评估磁场强度对神经放射学临床实践中磁共振成像（MRI）放射组学特征的影响。
使用同一制造商的两台临床MR设备，在两种不同磁场（1.5T和3T）下，对两个体模和10名健康志愿者采集T1 3D SPGR序列。体模在钆浓度和纹理异质性方面有所不同。使用LIFEX软件分割27个感兴趣区域（体模：21个，志愿者：6个）。分析了34个特征。
在体模数据集中，15个放射组学特征中的10个（67%）在1.5T或3T测量时存在显著差异（学生t检验，p<0.05）。灰度重采样和像素大小也会影响部分纹理特征。这些发现在健康志愿者中得到了验证。
根据临床检查的日常使用方案，在评估纹理特征时，1.5T上提取的放射组学特征不应与3T上的特征互换使用。在将研究结果应用于不同平台或设计多中心试验时，应调整这种混杂因素。
