Hussain Muhammad Ajaz, Ali Arshad, Alsahli Tariq G, Khan Nadia, Sharif Ahsan, Haseeb Muhammad Tahir, Alsaidan Omar Awad, Tayyab Muhammad, Bukhari Syed Nasir Abbas
Centre for Organic Chemistry, School of Chemistry, University of the Punjab, Lahore 54590, Pakistan.
Institute of Chemistry, University of Sargodha, Sargodha 40100, Pakistan.
Gels. 2023 Jun 28;9(7):525. doi: 10.3390/gels9070525.
The current research work focuses on the extraction and optimization of the hydrogel (AVM) from the seeds of using Box-Behnken design-response surface methodology (BBD-RSM). The AVM was obtained through a hot water extraction process. The influence of different factors, including pH (U = 4 to 10), temperature (V = 25 to 110 °C), seed/water ratio, i.e., S/W ratio (W = 1/10 to 1/70 /), and seed/water contact time, i.e., S/W time (X = 1 to 12 h) on the yield of AVM was evaluated. The -value for the analysis of variance (ANOVA) was found to be <0.001, indicating that the yield of AVM mainly depended on the abovementioned factors. The highest yield of AVM, i.e., 15.86%, was found at a pH of 7.12, temperature of 80.04 °C, S/W ratio of 1/33.24 /, and S/W time of 8.73 h according to Design-Expert Software. The study of the pH-responsive behavior of AVM in tablet form (formulation AVT3) revealed that AVM is a pH-responsive material with significantly high swelling at pH 7.4. However, less swelling was witnessed at pH 1.2. Moreover, AVM was found to be a sustained release material for esomeprazole at pH 7.4 for 12 h. The drug release from AVT3 was according to the super case-II transport mechanism and zero-order kinetics.
当前的研究工作聚焦于使用Box-Behnken设计-响应面法（BBD-RSM）从[种子名称未给出]种子中提取水凝胶（AVM）并进行优化。AVM通过热水提取工艺获得。评估了不同因素，包括pH值（U = 4至10）、温度（V = 25至110°C）、种子/水比例，即S/W比例（W = 1/10至1/70 /）以及种子/水接触时间，即S/W时间（X = 1至12小时）对AVM产量的影响。方差分析（ANOVA）的p值<0.001，表明AVM的产量主要取决于上述因素。根据Design-Expert软件，在pH值为7.12、温度为80.04°C、S/W比例为1/33.24 /以及S/W时间为8.73小时时，AVM的产量最高，即15.86%。对片剂形式（制剂AVT3）的AVM的pH响应行为研究表明，AVM是一种pH响应材料，在pH 7.4时具有显著的高溶胀性。然而，在pH 1.2时溶胀较小。此外，发现AVM在pH 7.4时是埃索美拉唑的缓释材料，持续12小时。AVT3的药物释放符合超级案例-II转运机制和零级动力学。
