Belfort M A, Moore P J
Department of Obstetrics and Gynaecology, Edendale Hospital, Pietermaritzburg.
S Afr Med J. 1988 Sep 17;74(6):265-7.
The calcium antagonist verapamil was infused intravenously in 10 patients with severe postpartum gestational proteinuric hypertension. A rapid and significant fall in systolic (P less than 0.01) and diastolic (P less than 0.02) blood pressure was seen within 5 minutes and was maintained for the duration of the infusion. No significant pulse rate changes were seen during the period of maximal blood pressure decrease. The principal side-effects were cutaneous flushing and headache. To our knowledge, this is the first recorded study on the use of verapamil in postpartum gestational proteinuric hypertension and the apparent efficacy of this drug justifies further investigation.
对10例重度产后妊娠蛋白尿性高血压患者静脉输注钙拮抗剂维拉帕米。5分钟内收缩压（P<0.01）和舒张压（P<0.02）迅速且显著下降，并在输注期间持续保持。在血压最大降幅期间未观察到明显的脉搏率变化。主要副作用为皮肤潮红和头痛。据我们所知，这是关于维拉帕米用于产后妊娠蛋白尿性高血压的首次记录研究，该药物的明显疗效证明有必要进一步研究。
