Walters B N, Redman C W
Br J Obstet Gynaecol. 1984 Apr;91(4):330-6. doi: 10.1111/j.1471-0528.1984.tb05918.x.
The calcium antagonist, nifedipine, was given orally to 21 women with acute episodes of severe hypertension during pregnancy or in the puerperium. A rapid and significant fall in blood pressure by an average of 26/20 mmHg was seen at 20 min after administration. The hypotensive effect was not significantly enhanced in those women already taking medication to lower the blood pressure. The principal side effects were headache and cutaneous flushing. No adverse fetal effects were detected. This is the first study of the use of this drug to control hypertension in pregnancy. The apparent efficacy of nifedipine justifies its further investigation in controlled trials.
对21名在孕期或产褥期出现严重高血压急性发作的女性口服钙拮抗剂硝苯地平。给药后20分钟可见血压迅速且显著下降，平均下降26/20 mmHg。在那些已经服用降压药的女性中，降压效果并未显著增强。主要副作用为头痛和皮肤潮红。未检测到对胎儿的不良影响。这是首次关于使用该药物控制孕期高血压的研究。硝苯地平明显的疗效证明有必要在对照试验中对其作进一步研究。
