Department of Physiotherapy, University of Bydgoszcz, 85-059 Bydgoszcz, Poland.
Department of Neurosurgery, 10th Military Research Hospital, 85-681 Bydgoszcz, Poland.
Int J Environ Res Public Health. 2021 Jun 12;18(12):6390. doi: 10.3390/ijerph18126390.
Epilepsy is a common consequence of brain tumors, occurring in 35 to 75% of cases. Here we evaluated the influence of epilepsy on the quality of life (QoL) of patients with malignant brain tumors (primary and metastatic) and assessed which areas of function are most affected by epilepsy and brain tumors. Sixty patients undergoing brain tumor surgery at the Neurosurgery Clinic of the 10th Military Research Hospital, Bydgoszcz, Poland (30 with epilepsy and 30 without epilepsy) were studied. Relationships between categorical variables were determined with Pearson's chi-squared test, while continuous data were analyzed with the Mann-Whitney U-test. A value < 0.05 was considered statistically significant. A multiple regression model was used for multivariate analysis of QoL. Patients with epilepsy more frequently reported memory disorders as a problem in their daily life. There were trends towards greater impairments in social, professional, and family life, sports and recreational activities, and daily physical activities in brain tumor patients with epilepsy rather than those without epilepsy. Higher frequency and generalized seizures significantly and adversely influenced the ability of patients to leave home and drive vehicles, but a proportion of patients with frequent, generalized seizures continued to drive regardless. Patients with generalized seizures considered the adverse effects of taking medicines as significantly disruptive. Memory disorders significantly affect the QoL of patients with epilepsy, and the importance of stopping driving must be emphasized by all healthcare professionals.
癫痫是脑瘤的常见后果，在 35%至 75%的病例中发生。在这里，我们评估了癫痫对恶性脑瘤（原发性和转移性）患者生活质量（QoL）的影响，并评估了哪些功能领域受癫痫和脑瘤影响最大。在波兰比得哥什第 10 军事研究医院神经外科诊所接受脑瘤手术的 60 名患者（30 名癫痫患者和 30 名非癫痫患者）参与了这项研究。使用 Pearson 卡方检验确定分类变量之间的关系，而使用 Mann-Whitney U 检验分析连续数据。 值<0.05 被认为具有统计学意义。使用多元回归模型对 QoL 进行多变量分析。有癫痫的患者更频繁地报告记忆障碍是日常生活中的一个问题。与无癫痫的患者相比，癫痫患者的社会、职业和家庭生活、体育和娱乐活动以及日常身体活动方面的障碍趋势更大。更高频率和全身性发作显著且不利地影响了患者离家和驾驶车辆的能力，但相当一部分频繁发生全身性发作的患者仍继续驾驶。全身性发作患者认为服用药物的不良影响显著干扰了日常生活。记忆障碍显著影响癫痫患者的 QoL，所有医疗保健专业人员都必须强调停止驾驶的重要性。
