Laboratoire des Biomolécules, LBM, Département de Chimie, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 75005 Paris, France.
Molecules. 2021 Jun 3;26(11):3381. doi: 10.3390/molecules26113381.
This contribution is an attempt to evoke the favorable atmosphere that prevailed in Lausanne around 1986 and provided the backdrop of our invention of two-dimensional ion cyclotron resonance mass spectroscopy (2D ICR-MS). To avoid a self-centered , we shall try to emphasize the context: the contributions of key players within our nascent research group at UNIL and the established group of Tino Gäumann at EPFL, the role of external speakers, and the open atmosphere that was not yet polluted by bibliometrics, obsessive concern with impact factors, and top-down management of research. We shall also explain why the idea of 2D ICR-MS has been ignored for many years and still has a limited impact: different scientific cultures in the ICR and NMR communities, different concerns with fundamental vs. applied research, different status of theory and numerical simulations, different levels of commitment of instrument manufacturers, not to mention many theoretical problems that appear to be at least as challenging in ICR as in NMR.
这篇文章旨在营造 1986 年左右洛桑的那种有利氛围,为我们二维离子回旋共振质谱(2D ICR-MS)的发明提供背景。为避免以自我为中心,我们将尝试强调背景:我们在 UNIL 新兴研究小组和 Tino Gäumann 在 EPFL 的成熟研究小组中的关键人物的贡献、外部演讲者的作用以及开放的氛围,这种氛围尚未受到文献计量学、对影响因素的过分关注以及自上而下的研究管理的污染。我们还将解释为什么 2D ICR-MS 的想法多年来一直被忽视,并且仍然影响有限:离子回旋共振和 NMR 两个社区的科学文化不同,对基础研究与应用研究的关注不同,理论和数值模拟的地位不同,仪器制造商的投入程度也不同,更不用说在 ICR 中出现的许多理论问题,这些问题似乎至少与在 NMR 中一样具有挑战性。