Transcriptomic Landscape of Lower Grade Glioma Based on Age-Related Non-Silent Somatic Mutations.

Glioma accounts for 80% of all malignant brain tumours and is the most common adult primary brain tumour. Age is an important factor affecting the development of cancer, as somatic mutations accumulate with age. Here, we aimed to analyse the significance of age-dependent non-silent somatic mutations in glioma prognosis. Histological tumour grade depends on age at diagnosis in patients with , , , and mutations. Age of patients with wild-type and increased with increase in tumour grade, while the age of patients with or mutation remained constant. However, the age of patients with mutation was higher than that of patients with mutation. The hierarchical clustering of patients was dominantly separated by and mutations. Furthermore, patients with mutation were dominantly separated by and double mutation and its double wild-type counterpart. The age of patients with and mutation was lower than that of patients with wild-type and . Patients with the double mutation showed poorer prognosis than those with the double wild type genotype. Unlike mutant, wild-type showed upregulation of expression of epithelial mesenchymal transition associated genes.