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槲皮素:一种具有心血管和神经保护益处的生物活性化合物:探索新鲜农产品、其废弃物及副产品的研究范围

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products.

作者信息

Bhat Irshad Ul Haq, Bhat Rajeev

机构信息

ERA-Chair for Food (By-) Products Valorisation Technologies (VALORTECH), Estonian University of Life Sciences, 51006 Tartu, Estonia.

出版信息

Biology (Basel). 2021 Jun 26;10(7):586. doi: 10.3390/biology10070586.

Abstract

Quercetin, a bioactive secondary metabolite, holds incredible importance in terms of bioactivities, which has been proved by in vivo and in vitro studies. The treatment of cardiovascular and neurological diseases by quercetin has been extensively investigated over the past decade. Quercetin is present naturally in appreciable amounts in fresh produce (fruits and vegetables). However, today, corresponding to the growing population and global demand for fresh fruits and vegetables, a paradigm shift and focus is laid towards exploring industrial food wastes and/or byproducts as a new resource to obtain bioactive compounds such as quercetin. Based on the available research reports over the last decade, quercetin has been suggested as a reliable therapeutic candidate for either treating or alleviating health issues, mainly those of cardiovascular and neurological diseases. In the present review, we have summarized some of the critical findings and hypotheses of quercetin from the available databases foreseeing its future use as a potential therapeutic agent to treat cardiovascular and neurological diseases. It is anticipated that this review will be a potential reference material for future research activities to be undertaken on quercetin obtained from fresh produce as well as their respective processing wastes/byproducts that rely on the circular concept.

摘要

槲皮素是一种生物活性次生代谢产物,其生物活性具有极其重要的意义,这已得到体内和体外研究的证实。在过去十年中,人们对槲皮素治疗心血管疾病和神经疾病进行了广泛研究。槲皮素在新鲜农产品(水果和蔬菜)中天然大量存在。然而,如今,随着人口增长以及全球对新鲜水果和蔬菜需求的增加,人们的观念发生了转变,开始将重点放在探索工业食品废料和/或副产品上,将其作为获取槲皮素等生物活性化合物的新资源。根据过去十年的现有研究报告,槲皮素已被认为是治疗或缓解健康问题(主要是心血管疾病和神经疾病)的可靠治疗候选物。在本综述中,我们从现有数据库中总结了槲皮素的一些关键发现和假设,展望其未来作为治疗心血管疾病和神经疾病的潜在治疗剂的用途。预计本综述将成为未来对从新鲜农产品及其各自加工废料/副产品中获得的槲皮素开展研究活动的潜在参考资料,这些研究活动依赖循环理念。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f12e/8301140/31caf3fa85d5/biology-10-00586-g001.jpg

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