RIKEN Center for Biosystems Dynamics Research, Laboratory for Cellular Function Imaging, 6-7-3 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
RIKEN-JEOL Collaboration Center, Multi-Modal Microstructure Analysis Unit, 6-7-3 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Nutrients. 2021 Jun 18;13(6):2091. doi: 10.3390/nu13062091.
Alpha-glycerylphosphorylcholine (αGPC) is a precursor of acetylcholine and can increase acetylcholine concentration in the brain. In addition, αGPC has a role in cholinergic function as well as monoaminergic transmission, including dopaminergic and serotonergic systems. These monoaminergic systems are related to feelings and emotions, including motivation, reward processing, anxiety, and depression. However, the precise effects of αGPC on human feelings and emotions remain to be elucidated. In this study, we investigated changes in the subjective feelings of healthy volunteers using the KOKORO scale before and after administering αGPC. Thirty-nine volunteers participated in a single-blind, placebo-controlled design. Participants completed a KOKORO scale test to quantify self-reported emotional states, three times each day for two weeks preceding treatment and then for a further two weeks while self-administering treatment. αGPC treatment show a tendency to increase motivation during the intervention period. Furthermore, motivation at night was significantly higher in the αGPC group than in the placebo group ( < 0.05). However, αGPC did not show any effects on anxiety. These data suggest that αGPC can be used to increase motivation in healthy individuals.
α-甘油磷酸胆碱（αGPC）是乙酰胆碱的前体，可以增加大脑中的乙酰胆碱浓度。此外，αGPC 在胆碱能功能以及单胺能传递中发挥作用，包括多巴胺能和 5-羟色胺能系统。这些单胺能系统与感觉和情绪有关，包括动机、奖励处理、焦虑和抑郁。然而，αGPC 对人类感觉和情绪的确切影响仍有待阐明。在这项研究中，我们使用 KOKORO 量表在给予 αGPC 前后调查了健康志愿者的主观感受的变化。39 名志愿者参加了一项单盲、安慰剂对照设计的研究。参与者在治疗前两周和治疗期间的两周内，每天三次完成 KOKORO 量表测试，以量化自我报告的情绪状态。αGPC 治疗在干预期间表现出增加动机的趋势。此外，αGPC 组夜间的动机明显高于安慰剂组（<0.05）。然而，αGPC 对焦虑没有任何影响。这些数据表明，αGPC 可用于增加健康个体的动机。
