Centre Environment & Health, Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, Belgium.
Centre for Environmental Sciences, Hasselt University, 3500 Hasselt, Belgium.
Nutrients. 2021 Jun 11;13(6):2012. doi: 10.3390/nu13062012.
Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. We studied mother-child pairs enrolled in the Maternal Nutrition and Offspring's Epigenome (MANOE) cohort, Leuven, Belgium. To calculate the dietary vitamin D intake, 108 women were asked to keep track of their diet using the seven-day estimated diet record (EDR) method. TL was assessed in 108 cord blood using a quantitative real-time PCR method. In each trimester of pregnancy, maternal serum 25-hydroxyvitamin D (25-OHD) concentration was measured. We observed a positive association (β = 0.009, -value = 0.036) between newborn average relative TL and maternal vitamin D intake (diet + supplement) during the first trimester. In contrast, we found no association between average relative TL of the newborn and mean maternal serum 25-OHD concentrations during pregnancy. To conclude, vitamin D intake (diet + supplements), specifically during the first trimester of pregnancy, is an important factor associated with TL at birth.
孕期营养对子代健康很重要。妊娠期维生素 D 的摄入可能预防多种不良结局，并且可能对后代端粒长度（TL）有影响。本研究旨在评估孕期母体维生素 D 摄入与新生儿 TL 之间的关联，以脐带血 TL 反映。我们研究了比利时鲁汶的母婴营养和后代表观基因组（MANOE）队列中的母婴对。为了计算膳食维生素 D 的摄入量，108 名妇女被要求使用 7 天估计饮食记录（EDR）方法记录饮食。使用实时定量 PCR 方法评估了 108 份脐带血中的 TL。在妊娠的每个三个月，测量母体血清 25-羟基维生素 D（25-OHD）浓度。我们观察到新生儿平均相对 TL 与妊娠早期母体维生素 D 摄入（饮食+补充剂）之间存在正相关（β=0.009，-值=0.036）。相比之下，我们未发现妊娠期间母体血清 25-OHD 浓度与新生儿平均相对 TL 之间存在关联。总之，维生素 D 摄入（饮食+补充剂），特别是在妊娠早期，是与出生时 TL 相关的重要因素。
