• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

4,5-二茂铁基-1,2-二硫醇-3-硫酮

4,5-Diferrocenyl-1,2-di-thiole-3-thione.

作者信息

Sánchez-García Jessica J, Flores-Alamo Marcos, Nuñez-Gordillo Amairany, Klimova Elena I

机构信息

Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, 04510, Mexico.

出版信息

IUCrdata. 2022 Oct 25;7(Pt 10):x221011. doi: 10.1107/S2414314622010112. eCollection 2022 Oct.

DOI:10.1107/S2414314622010112
PMID:36405852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9638058/
Abstract

The structure of 4,5-diferrocenyl-1,2-di-thiole-3-thione, [Fe(CH)(CHS)] or CHFeS, at 130 K has monoclinic (2/) symmetry. The molecule has two ferrocenyl units attached to a 1,2-di-thiole-3-thione moiety. It is of inter-est with respect to the question if the introduction of ferrocenyl substituents into biologically active mol-ecules offers the potential to obtain more efficacious therapeutic drugs. The crystal structure displays inter-molecular contacts of the C-H⋯S and S-π(C-C) types.

摘要

4,5-二茂铁基-1,2-二硫醇-3-硫酮，即[Fe(CH)(CHS)]或CHFeS，在130 K时具有单斜晶系（2/）对称性。该分子有两个二茂铁基单元连接到一个1,2-二硫醇-3-硫酮部分。就将二茂铁基取代基引入生物活性分子是否有可能获得更有效的治疗药物这一问题而言，它很有趣。晶体结构显示出C-H⋯S和S-π(C-C)类型的分子间接触。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/9638058/71dda4837e11/x-07-x221011-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/9638058/22f114478f7c/x-07-x221011-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/9638058/71dda4837e11/x-07-x221011-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/9638058/22f114478f7c/x-07-x221011-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6813/9638058/71dda4837e11/x-07-x221011-fig2.jpg

相似文献

1
4,5-Diferrocenyl-1,2-di-thiole-3-thione.4,5-二茂铁基-1,2-二硫醇-3-硫酮
IUCrdata. 2022 Oct 25;7(Pt 10):x221011. doi: 10.1107/S2414314622010112. eCollection 2022 Oct.
2
Crystal structure, Hirshfeld surface analysis and spectroscopic characterization of the di-enol tautomeric form of the compound 3,3'-[(2-sulf-an-yl-idene-1,3-di-thiole-4,5-di-yl)bis-(sulfane-di-yl)]bis-(pentane-2,4-dione).化合物3,3'-[(2-硫亚基-1,3-二噻吩-4,5-二亚基)双(硫烷二亚基)]双(戊烷-2,4-二酮)二烯醇互变异构体的晶体结构、 Hirshfeld表面分析和光谱表征
Acta Crystallogr E Crystallogr Commun. 2020 Aug 11;76(Pt 9):1427-1432. doi: 10.1107/S2056989020010695. eCollection 2020 Sep 1.
3
2-(1,3-Di-thiol-2-yl-idene)-1,3-di-thiole-4-carbaldehyde.2-（1,3-二硫醇-2-亚基）-1,3-二硫杂环戊烯-4-甲醛
Acta Crystallogr Sect E Struct Rep Online. 2013 Jun 26;69(Pt 7):o1157. doi: 10.1107/S160053681301711X. eCollection 2013.
4
Crystal structure of (±)-1-({[4-(all-yloxy)phen-yl]sulfan-yl}meth-yl)-2-(di-phenyl-thio-phosphor-yl)ferrocene.（±）-1-（{[4-（烯丙氧基）苯基]硫烷基}甲基）-2-（二苯基硫代磷酰基）二茂铁的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Jul 29;71(Pt 8):972-5. doi: 10.1107/S2056989015013560. eCollection 2015 Aug 1.
5
Synthesis and crystal structure of 3-phenyl-1,4,2-di-thia-zole-5-thione.3-苯基-1,4,2-二噻唑-5-硫酮的合成与晶体结构
Acta Crystallogr E Crystallogr Commun. 2022 Sep 13;78(Pt 10):1006-1009. doi: 10.1107/S205698902200888X. eCollection 2022 Oct 1.
6
Crystal and mol-ecular structures of a binuclear mixed ligand complex of silver(I) with thio-cyanate and 1-1,2,4-triazole-5(4)-thione.银（I）与硫氰酸盐和1,2,4-三唑-5（4）-硫酮的双核混合配体配合物的晶体结构和分子结构
Acta Crystallogr E Crystallogr Commun. 2020 Jan 1;76(Pt 1):42-47. doi: 10.1107/S2056989019016359.
7
The crystal structure of a new ferrocenyl P,N ligand: 1-[(2,2-di-methyl-hydrazin-1-yl-idene)meth-yl]-1'-(di-phenyl-phospho-rothio-yl)ferrocene.
Acta Crystallogr E Crystallogr Commun. 2018 Jan 12;74(Pt 2):133-136. doi: 10.1107/S2056989018000440. eCollection 2018 Feb 1.
8
Crystal structure of 3-[(4-benzyl-piperazin-1-yl)meth-yl]-5-(thio-phen-2-yl)-2,3-di-hydro-1,3,4-oxa-diazole-2-thione.3-[(4-苄基-哌嗪-1-基)甲基]-5-(噻吩-2-基)-2,3-二氢-1,3,4-恶二唑-2-硫酮的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Feb 13;71(Pt 3):o175-6. doi: 10.1107/S2056989015002273. eCollection 2015 Mar 1.
9
Crystal structure of 3,3'-diisopropyl-1,1'-(pyridine-2,6-di-yl)bis-[1H-imidazole-2(3H)-thione].3,3'-二异丙基-1,1'-(吡啶-2,6-二基)双-[1H-咪唑-2(3H)-硫酮]的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Mar 25;71(Pt 4):o255. doi: 10.1107/S2056989015005642. eCollection 2015 Apr 1.
10
Structural diversity in copper(I) iodide complexes with 6-thioxopiperidin-2-one, piperidine-2,6-di-thione and isoindoline-1,3-di-thione ligands.碘化亚铜与6-硫代哌啶-2-酮、哌啶-2,6-二硫酮和异吲哚啉-1,3-二硫酮配体形成的配合物中的结构多样性
Acta Crystallogr E Crystallogr Commun. 2020 Jul 21;76(Pt 8):1336-1344. doi: 10.1107/S2056989020009676. eCollection 2020 Aug 1.

本文引用的文献

1
Synthesis and Reactivity of 3-1,2-dithiole-3-thiones.3-1,2-二硫杂环戊烯-3-硫酮的合成与反应性。
Molecules. 2021 Jun 11;26(12):3595. doi: 10.3390/molecules26123595.
2
: from visualization to analysis, design and prediction.从可视化到分析、设计与预测。
J Appl Crystallogr. 2020 Feb 1;53(Pt 1):226-235. doi: 10.1107/S1600576719014092.
3
Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress.硫化氢供体对抗氧化应激的神经保护作用的潜在机制。
Neurochem Int. 2013 Jun;62(8):1072-8. doi: 10.1016/j.neuint.2013.04.001. Epub 2013 Apr 12.
4
Different donor-acceptor structures of dithiafulvalene-fused semiconducting polymers with different band gaps.具有不同带隙的二噻吩并富勒烯-稠合半导体聚合物的不同给体-受体结构。
Chem Commun (Camb). 2011 Oct 7;47(37):10401-3. doi: 10.1039/c1cc13511b. Epub 2011 Aug 12.
5
Design, synthesis, and pharmacological evaluation of the aqueous prodrugs of desmethyl anethole trithione with hepatoprotective activity.具有保肝活性的去甲茴香三硫醚水前药的设计、合成及药效学评价。
Eur J Med Chem. 2010 Jul;45(7):3005-10. doi: 10.1016/j.ejmech.2010.03.029. Epub 2010 Mar 25.
6
Identification of dithiolethiones with better chemopreventive properties than oltipraz.
Carcinogenesis. 1998 Sep;19(9):1609-15. doi: 10.1093/carcin/19.9.1609.