Koskela P, Nurmi T, Häiva V M
National Public Health Institute, Kuopio, Finland.
Vaccine. 1988 Jun;6(3):221-2. doi: 10.1016/0264-410x(88)90214-9.
Pneumococcal polysaccharide vaccine contaminated with blood group A-like substance stimulated long-lasting production of anti-A antibodies in 10 of 11 subjects with O or B blood group. ELISA using blood group A substance as antigen detected increased IgA anti-A levels 18 months after vaccination in 82% of O and B subjects, the corresponding values being 73% for IgG and 18% for IgM. In females of O or B blood group becoming pregnant with a fetus of group A or AB, prior immunization to blood group A substance may cause a potential risk for haemolytic disease of the newborn.
被类 A 血型物质污染的肺炎球菌多糖疫苗在 11 名 O 型或 B 型血的受试者中有 10 人刺激产生了持久的抗 A 抗体。以 A 血型物质作为抗原的酶联免疫吸附测定（ELISA）检测发现，82%的 O 型和 B 型受试者在接种疫苗 18 个月后 IgA 抗 A 水平升高，IgG 为 73%，IgM 为 18%。在 O 型或 B 型血的女性怀有 A 型或 AB 型胎儿时，先前对 A 血型物质的免疫接种可能会给新生儿溶血病带来潜在风险。
