Boyer K M, Theeravuthichai J, Vogel L C, Orlina A, Gotoff S P
J Pediatr. 1981 Mar;98(3):374-8. doi: 10.1016/s0022-3476(81)80698-1.
The effect of pneumococcal vaccination on antibodies to Streptococcus pneumoniae type 14, group B streptococcus type III, and AB blood group antigens was studied in 40 vaccinated adults. Fourfold or greater increases in type-specific IgG antibody to Pn-14 were found in 26 of 40 vaccines (mean increase 6.4-fold) and against GBS-III in 16 of the 40 (mean increase 2.9-fold) by an indirect immunofluorescence assay. However, only six of the 26 vaccinees with low levels (titers less than or equal to 20) of GBS-III antibody in prevaccination sera developed titers greater than 20 after vaccination. Thus, vaccination with polyvalent pneumococcal vaccine does not reliably induce high levels of IF antibody to GBS-III. Fourfold or greater increases in IgG isohemagglutinins against blood group A cells were also found in 22 of 27 vaccines (mean increase 4.5-fold) and against blood group B cells in nine of 34 (mean increase 1.7-fold) using the indirect anti-human globulin test. Chromatographic fractionation of selected sera confirmed that the anti-A isohemagglutinins stimulated in group O subjects were of the IgG class. Thus, pneumococcal vaccination during incompatible pregnancy could potentiate AO hemolytic disease of the newborn infant.
在40名接种疫苗的成年人中研究了肺炎球菌疫苗接种对14型肺炎链球菌、III型B族链球菌和AB血型抗原抗体的影响。通过间接免疫荧光测定法，40名接种者中有26人（平均增加6.4倍）对Pn-14的型特异性IgG抗体增加了四倍或更多，40人中有16人（平均增加2.9倍）对GBS-III的抗体增加。然而，接种前血清中GBS-III抗体水平低（滴度小于或等于20）的26名接种者中，只有6人在接种后滴度大于20。因此，接种多价肺炎球菌疫苗不能可靠地诱导产生高水平的针对GBS-III的IF抗体。使用间接抗人球蛋白试验，27名接种者中有22人（平均增加4.5倍）对A血型细胞的IgG同种血凝素增加了四倍或更多，34名接种者中有9人（平均增加1.7倍）对B血型细胞的同种血凝素增加。对选定血清进行色谱分离证实，O型血受试者中刺激产生的抗A同种血凝素属于IgG类。因此，在不相容妊娠期间接种肺炎球菌疫苗可能会增强新生儿的AO溶血病。
