Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar 190006, Jammu and Kashmir, India.
Houston Methodist Research Institute, Houston, TX 77030, USA.
Genes (Basel). 2021 Jun 29;12(7):1000. doi: 10.3390/genes12071000.
Packaging of the eukaryotic genome with histone and other proteins forms a chromatin structure that regulates the outcome of all DNA mediated processes. The cellular pathways that ensure genomic stability detect and repair DNA damage through mechanisms that are critically dependent upon chromatin structures established by histones and, particularly upon transient histone post-translational modifications. Though subjected to a range of modifications, histone methylation is especially crucial for DNA damage repair, as the methylated histones often form platforms for subsequent repair protein binding at damaged sites. In this review, we highlight and discuss how histone methylation impacts the maintenance of genome integrity through effects related to DNA repair and repair pathway choice.
真核生物基因组与组蛋白和其他蛋白质一起包装形成染色质结构，这种结构调节所有 DNA 介导的过程的结果。通过机制来确保基因组稳定性的细胞途径可以检测和修复 DNA 损伤，这些机制严重依赖于组蛋白建立的染色质结构，特别是依赖于组蛋白翻译后修饰的瞬时性。尽管受到各种修饰的影响，但组蛋白甲基化对于 DNA 损伤修复尤为重要，因为甲基化的组蛋白通常在受损部位为随后的修复蛋白结合形成平台。在这篇综述中，我们强调并讨论了组蛋白甲基化如何通过与 DNA 修复和修复途径选择相关的影响来影响基因组完整性的维持。
