母亲铅暴露与早产风险的关联：一项荟萃分析。
Association of maternal lead exposure with the risk of preterm: a meta-analysis.
机构信息
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Department of Molecular Systems Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
出版信息
J Matern Fetal Neonatal Med. 2022 Dec;35(25):7222-7230. doi: 10.1080/14767058.2021.1946780. Epub 2021 Jul 1.
BACKGROUND
The relationship between maternal lead level and risk of preterm birth (PTB) remained controversial. Therefore, herein we performed this meta-analysis to investigate the association of maternal blood, urine and cord blood lead level with the risk of PTB using observational studies.
METHODS
A systematic search was conducted in PubMed, EMBASE and Ovid Medline databases from inception to August 2019, and sixteen studies with 65600 participants investigating the association between maternal lead level and PTB were included in our meta-analysis. Odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated for the highest versus lowest lead level by random-effects model.
RESULTS
Overall, the pooled OR of all included articles for the highest versus lowest PTB score was 1.29 (95% CI = 1.14-1.46; I2 = 80.4%, < .001), and the results revealed a direct and significant relationship between second and third trimester blood lead level (BLL) and PTB (OR 2nd trimester= 1.61, 95% CI = 1.08-2.40, OR 3rd trimester= 1.57, 95% CI = 1.11-2.23).
CONCLUSION
Results of this meta-analysis showed that maternal BLL is directly associated with the risk of PTB.
背景
母体血铅水平与早产（PTB）风险之间的关系仍存在争议。因此，本研究通过观察性研究，采用荟萃分析来评估母体血液、尿液和脐血铅水平与 PTB 风险之间的关系。
方法
从建库到 2019 年 8 月，我们在 PubMed、EMBASE 和 Ovid Medline 数据库中进行了系统检索，纳入了 16 项研究，共 65600 名参与者，旨在研究母体铅水平与 PTB 之间的关系。采用随机效应模型计算最高与最低铅水平之间的比值比（OR）和 95%置信区间（95%CI）。
结果
总体而言，所有纳入文章中最高与最低 PTB 评分之间的汇总 OR 为 1.29（95%CI=1.14-1.46；I2=80.4%，<.001），结果表明第二和第三孕期血铅水平（BLL）与 PTB 之间存在直接且显著的关系（OR 2nd trimester=1.61，95%CI=1.08-2.40，OR 3rd trimester=1.57，95%CI=1.11-2.23）。
结论
荟萃分析的结果表明，母体 BLL 与 PTB 风险直接相关。
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