美国 12-19 岁青少年血铅水平与甲状旁腺激素的关系：一项横断面研究。
Association between blood lead levels and parathyroid hormone among United States adolescents aged 12-19: a cross-sectional study.
机构信息
Center for Reproductive Medicine, Department of Pediatrics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.
Bengbu Medical College, Bengbu, Anhui, China.
出版信息
Front Endocrinol (Lausanne). 2024 Jul 9;15:1383058. doi: 10.3389/fendo.2024.1383058. eCollection 2024.
AIMS
Studies on the association between serum lead levels and parathyroid function in adolescents are lacking. Therefore, in this study, we elucidated the possible association between blood lead levels (BLLs) and the parathyroid hormone (PTH) in adolescents aged 12-19 years in the United States.
METHODS
In this study, information from the database of the National Health and Nutrition Examination Survey was utilized. The study included 3919 participants from survey cycles between 2003-2004 and 2005-2006. Multivariable linear regression analysis was performed to determine the correlation between BLLs and PTH. Furthermore, smooth curve fitting was utilized to analyze the dose-response relationship between BLLs and PTH.
RESULTS
Multivariable linear regression analysis revealed that every 1 μg/dL increase in BLLs was associated with 0.67 pg/mL increase in PTH (β = 0.67, 95% CI: 0.16-1.18, p < 0.01). However, sex-stratified subgroup analysis revealed that this positive association was only observed in males (β = 1.16, 95% CI: 0.50-1.83 p < 0.01). Smooth curve fitting revealed a positive correlation between BLLs and PTH.
CONCLUSIONS
In adolescents in the United States, BLLs are positively correlated with PTH, particularly in males.
目的
目前缺乏关于青少年血清铅水平与甲状旁腺功能之间关联的研究。因此，在这项研究中，我们阐明了美国 12-19 岁青少年血液铅水平（BLL）与甲状旁腺激素（PTH）之间可能存在的关联。
方法
本研究利用了国家健康和营养调查数据库中的信息。研究纳入了 2003-2004 年和 2005-2006 年调查周期中的 3919 名参与者。采用多变量线性回归分析来确定 BLL 与 PTH 之间的相关性。此外，还进行了平滑曲线拟合，以分析 BLL 与 PTH 之间的剂量-反应关系。
结果
多变量线性回归分析显示，BLL 每增加 1μg/dL，PTH 增加 0.67pg/mL（β=0.67，95%CI：0.16-1.18，p<0.01）。然而，按性别分层的亚组分析显示，这种正相关仅在男性中观察到（β=1.16，95%CI：0.50-1.83，p<0.01）。平滑曲线拟合显示 BLL 与 PTH 之间存在正相关关系。
结论
在美国青少年中，BLL 与 PTH 呈正相关，尤其是在男性中。
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