前列腺癌侵袭性的基础科学与分子遗传学

Basic Science and Molecular Genetics of Prostate Cancer Aggressiveness.

机构信息

Department of Urology, Urology Research Laboratory, Thomas Jefferson University, Sidney Kimmel Cancer Center, 233 South 10th Street BLSB 804, Philadelphia, PA 19107, USA; Department of Cancer Biology, Urology Research Laboratory, Thomas Jefferson University, Sidney Kimmel Cancer Center, 233 South 10th Street BLSB 804, Philadelphia, PA 19107, USA.

Department of Cancer Biology, Thomas Jefferson University, 233 South 10th Street BLSB 1050, Philadelphia, PA 19107, USA; Department of Urology, Thomas Jefferson University, 233 South 10th Street BLSB 1050, Philadelphia, PA 19107, USA; Department of Medical Oncology, Thomas Jefferson University, 233 South 10th Street BLSB 1050, Philadelphia, PA 19107, USA; Department of Radiation Oncology, Thomas Jefferson University, 233 South 10th Street BLSB 1050, Philadelphia, PA 19107, USA. Electronic address: https://twitter.com/SKCCDirector.

出版信息

Urol Clin North Am. 2021 Aug;48(3):339-347. doi: 10.1016/j.ucl.2021.04.004. Epub 2021 Jun 16.

DOI:10.1016/j.ucl.2021.04.004

PMID:34210489

Abstract

Androgen receptor function, tumor cell plasticity, loss of tumor suppressors, and defects in DNA repair genes affect aggressive features of prostate cancer. Prostate cancer development, progression, and aggressive behavior are often attributable to function of the androgen receptor. Tumor cell plasticity, neuroendocrine features, and loss of tumor suppressors lend aggressive behavior to prostate cancer cells. DNA repair defects have ramifications for prostate cancer cell behavior.

摘要

雄激素受体功能、肿瘤细胞可塑性、肿瘤抑制因子丢失和 DNA 修复基因缺陷影响前列腺癌的侵袭特征。前列腺癌的发生、发展和侵袭行为通常归因于雄激素受体的功能。肿瘤细胞可塑性、神经内分泌特征和肿瘤抑制因子丢失使前列腺癌细胞具有侵袭性。DNA 修复缺陷对前列腺癌细胞行为有影响。