蛋白淀粉样纤维辅因子：带电荷的侧链结构簇是否找到了它们的“另一半”？
Protein Amyloid Cofactors: Charged Side-Chain Arrays Meet Their Match?
机构信息
Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118, USA.
Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118, USA.
出版信息
Trends Biochem Sci. 2021 Aug;46(8):626-629. doi: 10.1016/j.tibs.2021.05.003. Epub 2021 Jun 28.
Abstract
Recent advances in high-resolution structural studies of protein amyloids have revealed parallel in-register cross-β-sheets with periodic arrays of closely spaced identical residues. What do these structures tell us about the mechanisms of action of common amyloid-promoting factors, such as heparan sulfate (HS), nucleic acids, polyphosphates, anionic phospholipids, and acidic pH?
摘要
近年来，对蛋白质淀粉样物的高分辨率结构研究取得了进展，揭示了具有周期性紧密间隔的相同残基排列的平行、在位的交叉-β-折叠片。这些结构告诉我们有关常见淀粉样物质促进因子（如肝素硫酸盐（HS）、核酸、多磷酸盐、阴离子磷脂和酸性 pH）作用机制的哪些信息？
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