Zhang Congdi, Zhang Yangyang, Zhu Mengqi, Zhang Chunyan, Lu Danyang, Jiang Jimin, Wang Zhiyong, Deng Peng, Qian Yun, Shen Minjuan, Chen Qianming
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310003, China.
Bioact Mater. 2025 May 21;51:469-493. doi: 10.1016/j.bioactmat.2025.04.036. eCollection 2025 Sep.
Amyloid deposits are widely presented in ectopic calcification associated with many degenerative diseases, such as calcific aortic valve disease and Alzheimer's disease. Recently, amyloid-like secondary structures have also been observed in matrix proteins during physiological mineralization processes. With advancing observational apparatus, the mineral-templating role of amyloid has been increasingly investigated; nevertheless, it is still challenging to elucidate the explicit contribution of amyloid-like proteins in both pathological and physiological calcification. In this review, we discuss the potential roles of amyloid-forming proteins in both pathological and physiological mineralization, the nature of the interactions between the amyloid-like structure and the mineral ions, as well as the mechanisms underlying hierarchical mineralization templated by amyloid proteins. Taking inspiration from nature's book, we summarize the cutting-edge developments in amyloid-based materials for hard tissue repair. Spanning from mechanisms to applications, this review provides valuable insights for further interdisciplinary research.
淀粉样沉积物广泛存在于与许多退行性疾病相关的异位钙化中，如钙化性主动脉瓣疾病和阿尔茨海默病。最近，在生理矿化过程中，基质蛋白中也观察到了淀粉样二级结构。随着观测仪器的进步，淀粉样蛋白的矿化模板作用受到了越来越多的研究；然而，阐明类淀粉样蛋白在病理和生理钙化中的具体作用仍然具有挑战性。在这篇综述中，我们讨论了形成淀粉样蛋白的蛋白质在病理和生理矿化中的潜在作用、类淀粉样结构与矿物离子之间相互作用的性质，以及淀粉样蛋白模板化分级矿化的潜在机制。从自然之书中汲取灵感，我们总结了用于硬组织修复的淀粉样基材料的前沿进展。从机制到应用，这篇综述为进一步的跨学科研究提供了有价值的见解。
