PhD Program in Biochemistry, The Graduate Center CUNY (City University of New York), New York, NY 10016, USA; Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA.
PhD Program in Biochemistry, The Graduate Center CUNY (City University of New York), New York, NY 10016, USA; Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA.
Trends Endocrinol Metab. 2021 Aug;32(8):579-593. doi: 10.1016/j.tem.2021.05.011. Epub 2021 Jun 28.
One carbon metabolism (OCM) is critical for early development, as it provides one carbon (1C) units for the biosynthesis of DNA, proteins, and lipids and epigenetic modification of the genome. Epigenetic marks established early in life can be maintained and exert lasting impacts on gene expression and functions later in life. Animal and human studies have increasingly demonstrated that prenatal 1C nutrient deficiencies impair fetal growth, neurodevelopment, and cardiometabolic parameters in childhood, while sufficient maternal 1C nutrient intake is protective against these detrimental outcomes. However, recent studies also highlight the potential risk of maternal 1C nutrient excess or imbalance in disrupting early development. Further studies are needed to delineate the dose-response relationship among prenatal 1C nutrient exposure, epigenetic modifications, and developmental outcomes.
一碳代谢（OCM）对早期发育至关重要，因为它为 DNA、蛋白质和脂质的生物合成以及基因组的表观遗传修饰提供一碳（1C）单位。生命早期建立的表观遗传标记可以被维持，并对生命后期的基因表达和功能产生持久的影响。动物和人类研究越来越多地表明，产前 1C 营养缺乏会损害胎儿的生长、神经发育和儿童时期的心脏代谢参数，而充足的母体 1C 营养摄入可以预防这些不良后果。然而，最近的研究也强调了母体 1C 营养过剩或失衡对早期发育的潜在风险。需要进一步的研究来描绘产前 1C 营养暴露、表观遗传修饰和发育结果之间的剂量-反应关系。
