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母亲饮食和生活方式对儿童肥胖风险的影响。

The Effect of Maternal Diet and Lifestyle on the Risk of Childhood Obesity.

作者信息

Łuszczki Edyta, Wyszyńska Justyna, Dymek Agnieszka, Drożdż Dorota, González-Ramos Laura, Hartgring Isa, García-Carbonell Nuria, Mazur Artur, Erdine Serap, Parnarauskienė Justė, Alvarez-Pitti Julio

机构信息

Institute of Health Sciences, Medical College of Rzeszów University, 35-959 Rzeszów, Poland.

Department of Pediatric Nephrology and Hypertension, Pediatric Institute, Jagiellonian University Medical College, 31-007 Krakow, Poland.

出版信息

Metabolites. 2024 Nov 25;14(12):655. doi: 10.3390/metabo14120655.

Abstract

: Childhood obesity is a global health problem that affects at least 41 million children under the age of five. Increased BMI in children is associated with serious long-term health consequences, such as type 2 diabetes, cardiovascular disease, and psychological problems, including depression and low self-esteem. Although the etiology of obesity is complex, research suggests that the diet and lifestyle of pregnant women play a key role in shaping metabolic and epigenetic changes that can increase the risk of obesity in their children. Excessive gestational weight gain, unhealthy dietary patterns (including the Western diet), and pregnancy complications (such as gestational diabetes) are some of the modifiable factors that contribute to childhood obesity. The purpose of this narrative review is to summarize the most important and recent information on the impact of the diet and lifestyle of pregnant women on the risk of childhood obesity. : This article is a narrative review that aims to summarize the available literature on the impact of pregnant women's diet and lifestyle on the risk of obesity in their offspring, with a focus on metabolic and epigenetic mechanisms. /: Current evidence suggests that a pregnant woman's lifestyle and diet can significantly contribute to lowering the risk of obesity in their offspring. However, further high-quality research is needed to understand better the metabolic and epigenetic relationships concerning maternal factors that predispose offspring to obesity.

摘要

儿童肥胖是一个全球性的健康问题,影响着至少4100万五岁以下的儿童。儿童体重指数(BMI)的增加与严重的长期健康后果相关,如2型糖尿病、心血管疾病以及包括抑郁和自卑在内的心理问题。尽管肥胖的病因很复杂,但研究表明,孕妇的饮食和生活方式在塑造代谢和表观遗传变化方面起着关键作用,这些变化会增加其子女肥胖的风险。孕期体重过度增加、不健康的饮食模式(包括西式饮食)以及妊娠并发症(如妊娠期糖尿病)是导致儿童肥胖的一些可改变因素。本叙述性综述的目的是总结关于孕妇饮食和生活方式对儿童肥胖风险影响的最重要和最新信息。 本文是一篇叙述性综述,旨在总结关于孕妇饮食和生活方式对其后代肥胖风险影响的现有文献,重点关注代谢和表观遗传机制。 目前的证据表明,孕妇的生活方式和饮食可显著有助于降低其后代肥胖的风险。然而,需要进一步的高质量研究,以更好地理解与使后代易患肥胖的母体因素相关的代谢和表观遗传关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3499/11679592/d79877153cc4/metabolites-14-00655-g001.jpg

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