Singh Anamika, Kumar Raj, Singh Naresh Pal, Yadav Ramakant, Kumar Arushi
Department of Physiology, Uttar Pradesh University of Medical Sciences, Etawah, Uttar Pradesh, India.
Department of Neurosurgery, Uttar Pradesh University of Medical Sciences, Etawah, Uttar Pradesh, India.
Asian J Neurosurg. 2021 Feb 23;16(1):99-105. doi: 10.4103/ajns.AJNS_331_20. eCollection 2021 Jan-Mar.
Traumatic brain injuries (TBIs) are the leading cause of morbidity, mortality, disability, and socioeconomic losses globally, but of more concern, in India and other developing countries. The Mini mental state examination (MMSE) and clock drawing test (CDT) are the two mostly adapted methods for cognitive impairment screening. Therefore, it is necessary to establish a robust evaluation system exclusively for post-TBI cognitive impairment.
One hundred and thirty-four cases treated previously at the health facility for TBIs were evaluated for cognitive functions during the follow-up period ranging from 3 weeks to 6 months in the out-patient department. All cases underwent mini-mental score examination (MMSE) and CDT to assess their cognitive performances. The data were analyzed statistically using Chi-square and ANOVA tests of significance.
Statistically significant association ( < 0.001) between the cognitive status of patients on the basis of overall MMSE score and the site of brain injury was observed. It was noted that 76 (56.7%) of the cases had cognitive impairment (MMSE score <24) with majority 44 (32.8%) patients having frontal lobe injuries, followed by 14 (10.1%) having brain injuries in the temporal lobe. On the other hand, using CDT score, it was observed that 102 (76.1%) of the cases had cognitive impairment (CDT score <5) with the majority 49 (36.6%) cases having frontal lobe injury followed by 19 (14.2%) having brain injury in the parietal lobe.
The CDT was able to access cognitive function disruption in those patients, in whom the mini-mental score examination was not able to assess the same, and this difference in detection capabilities of both the tests was statistically found significant.
创伤性脑损伤(TBI)是全球发病、死亡、残疾及社会经济损失的主要原因,在印度和其他发展中国家更是令人担忧。简易精神状态检查(MMSE)和画钟试验(CDT)是认知障碍筛查最常用的两种方法。因此,有必要建立一个专门针对创伤性脑损伤后认知障碍的强大评估系统。
对134例曾在医疗机构接受过创伤性脑损伤治疗的患者进行随访,随访期为3周-6个月,在门诊评估其认知功能。所有病例均接受简易精神状态评分检查(MMSE)和CDT以评估其认知表现。采用卡方检验和方差分析对数据进行统计学分析。
基于总体MMSE评分的患者认知状态与脑损伤部位之间存在统计学显著关联(<0.001)。值得注意的是,76例(56.7%)病例存在认知障碍(MMSE评分<24),其中大多数44例(32.8%)患者额叶受伤,其次是14例(10.1%)颞叶脑损伤患者。另一方面,使用CDT评分时,观察到102例(76.1%)病例存在认知障碍(CDT评分<5),其中大多数49例(36.6%)病例额叶受伤,其次是19例(14.2%)顶叶脑损伤患者。
CDT能够检测出那些简易精神状态评分检查无法评估出认知功能障碍的患者,并且统计学发现这两种测试的检测能力差异具有显著性。