Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-954 Lublin, Poland.
J Diabetes Res. 2021 Jun 9;2021:5547228. doi: 10.1155/2021/5547228. eCollection 2021.
The exact role of adipokines in the pathogenesis of gestational diabetes mellitus (GDM) still remains not fully clear, and multiple studies have analyzed their potential contribution to the pathophysiology of this pregnancy complication. This study is aimed at evaluating serum chemerin, lipocalin 2, and apelin concentrations in GDM and healthy pregnant patients, assessing the correlation between these adipokines, and suggesting the potential role of these cytokines in the diagnosis and pathophysiology of GDM. The study comprised 237 pregnant women: 153 with GDM and 84 with physiological pregnancy. Serum concentrations of chemerin, lipocalin 2, and apelin were obtained at 24-29 weeks of gestation. The mean concentrations of chemerin and lipocalin 2 were significantly higher in the GDM group. The concentration of apelin was slightly higher in the GDM group, but not statistically significant. The strong positive correlation between chemerin and lipocalin 2 concentrations was noticed in both groups. Our data suggest that maternal chemerin and lipocalin 2 may play a significant role in the pathophysiology of GDM. We imply that these adipokines could potentially be established as novel biomarkers for the early identification of GDM. However, more studies are needed to analyze the effect of these adipokines on glucose metabolism during early pregnancy.
脂肪因子在妊娠期糖尿病（GDM）发病机制中的确切作用尚不完全清楚，多项研究分析了它们对这种妊娠并发症病理生理学的潜在贡献。本研究旨在评估 GDM 和健康孕妇血清趋化素、脂联素 2 和脂联素的浓度，评估这些脂肪因子之间的相关性，并提示这些细胞因子在 GDM 的诊断和病理生理学中的潜在作用。该研究纳入了 237 名孕妇：153 名 GDM 患者和 84 名生理妊娠患者。在妊娠 24-29 周时获得血清趋化素、脂联素 2 和脂联素浓度。GDM 组趋化素和脂联素 2 的平均浓度明显较高。GDM 组中脂联素的浓度略高，但无统计学意义。在两组中均发现趋化素和脂联素 2 浓度之间存在强烈的正相关。我们的数据表明，母体趋化素和脂联素 2 可能在 GDM 的病理生理学中发挥重要作用。我们暗示，这些脂肪因子可能有潜力作为 GDM 早期识别的新型生物标志物。然而，需要更多的研究来分析这些脂肪因子对早期妊娠期间葡萄糖代谢的影响。
