Division of Life Science and Medicine, Department of Endocrinology, The First Affiliated Hospital of USTC (Anhui Provincial Hospital), University of Science and Technology of China, 17 Lujiang Road, Hefei, 230001, China.
Department of Rheumatology and Immunology, Arthritis Research Institute, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, 230022, Anhui, China.
Lipids Health Dis. 2020 Feb 22;19(1):26. doi: 10.1186/s12944-020-01209-7.
The available data on the significance of circulating apelin, chemerin and omentin in women with gestational diabetes mellitus (GDM) are inconsistent. This analysis includes a systematic review of the evidence associating the serum concentrations of these adipokines with GDM.
Publications through December 2019 were retrieved from PubMed, Embase, the Cochrane Library, and Web of Science. Subgroup analysis and meta-regression were conducted to evaluate sources of heterogeneity.
Analysis of 20 studies, including 1493 GDM patients and 1488 normal pregnant women did not find significant differences in circulating apelin and chemerin levels (apelin standardized mean difference [SMD] = 0.43, 95% confidence interval (CI): - 0.40 to 1.26, P = 0.31; chemerin SMD = 0.77, 95% CI - 0.07 to 1.61, P = 0.07). Circulating omentin was significantly lower in women with GDM than in healthy controls (SMD = - 0.72, 95% CI - 1.26 to - 0.19, P = 0.007). Publication bias was not found; sensitivity analysis confirmed the robustness of the pooled results.
Circulating omentin was decreased in GDM patients, but apelin and chemerin levels were not changed. The results suggest that omentin has potential as a novel biomarker for the prediction and early diagnosis of GDM.
关于循环脂联素、趋化素和网膜素在妊娠糖尿病（GDM）妇女中的意义，现有数据并不一致。本分析包括对这些脂肪因子与 GDM 相关的血清浓度的证据进行系统评价。
通过 PubMed、Embase、Cochrane 图书馆和 Web of Science 检索 2019 年 12 月之前的出版物。进行亚组分析和荟萃回归以评估异质性来源。
对 20 项研究（包括 1493 例 GDM 患者和 1488 例正常孕妇）进行分析，未发现循环脂联素和趋化素水平存在显著差异（脂联素标准化均数差 [SMD] = 0.43，95%置信区间 [CI]：-0.40 至 1.26，P = 0.31；趋化素 SMD = 0.77，95%CI -0.07 至 1.61，P = 0.07）。GDM 妇女的循环网膜素明显低于健康对照组（SMD = -0.72，95%CI -1.26 至 -0.19，P = 0.007）。未发现发表偏倚；敏感性分析证实了汇总结果的稳健性。
GDM 患者的循环网膜素降低，但脂联素和趋化素水平没有改变。结果表明，网膜素具有作为 GDM 预测和早期诊断的新型生物标志物的潜力。
