基线中性粒细胞/淋巴细胞比值（NLR）和红细胞分布宽度（RDW）与皮肤鳞状细胞癌的晚期阶段相关。

Baseline neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width (RDW) correlate with advanced stages in cutaneous squamous cell carcinoma.

机构信息

Department of Dermatology, University of Roma Tor Vergata, Rome, Italy.

Department of Plastic Surgery, San Giovanni Hospital, Rome, Italy.

出版信息

Int J Dermatol. 2022 Feb;61(2):175-179. doi: 10.1111/ijd.15755. Epub 2021 Jul 2.

DOI:10.1111/ijd.15755

PMID:34212366

Abstract

BACKGROUND

The neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width (RDW) at diagnosis have been shown to correlate with advanced disease and to be prognostic factors in many tumors. However, their role as a prognostic factor for cutaneous squamous cell carcinoma (cSCC) has not yet been studied.

OBJECTIVE

Therefore, the aim of our study was to evaluate the correlation of NLR and RDW with stages of disease in patients with cSCC in order to define whether or not higher values of these two markers correlate with a more aggressive disease.

METHODS

We retrospectively analyzed the NLR and RDW in a total of 51 newly diagnosed cSCC patients. NLR and RDW were calculated using data obtained from the complete blood count (CBC).

RESULTS

Median NLR among patients with the non-advanced disease (in situ and stage I) was 2.2, whereas median NLR for patients with advanced disease was 4.87. Median RDW among patients with early stage disease was 13.7%, while median RDW in patients with advanced disease was 15.81%. Statistical analysis showed positive associations of advanced cSCC stages with NLR or RDW higher than 3.07 or 14.5%, respectively.

CONCLUSIONS

Therefore, our analysis demonstrated how both NLR and RDW represent cheap and easily available factors that could be used as markers for advanced cSCC. They could help to identify patients with advanced stages disease that requires a strict follow-up.

摘要

背景

中性粒细胞/淋巴细胞比值（NLR）和红细胞分布宽度（RDW）在诊断时已被证明与疾病的进展有关，并且是许多肿瘤的预后因素。然而，它们作为皮肤鳞状细胞癌（cSCC）的预后因素的作用尚未得到研究。

目的

因此，我们研究的目的是评估 NLR 和 RDW 与 cSCC 患者疾病分期之间的相关性，以确定这两个标志物的较高值是否与更具侵袭性的疾病相关。

方法

我们回顾性分析了 51 例新诊断的 cSCC 患者的 NLR 和 RDW。NLR 和 RDW 使用来自全血细胞计数（CBC）的数据计算得出。

结果

非晚期疾病（原位和 I 期）患者的 NLR 中位数为 2.2，而晚期疾病患者的 NLR 中位数为 4.87。早期疾病患者的 RDW 中位数为 13.7%，而晚期疾病患者的 RDW 中位数为 15.81%。统计分析显示，晚期 cSCC 分期与 NLR 或 RDW 高于 3.07 或 14.5%呈正相关。