Pinna Antonio, Porcu Tiziana, Paliogiannis Panagiotis, Dore Stefano, Serra Rita, Boscia Francesco, Carru Ciriaco, Zinellu Angelo
Department of Medical, Surgical, and Experimental Sciences, University of Sassari, Sassari, Italy.
Azienda Ospedaliero-Universitaria di Sassari, Sassari, Italy.
Acta Ophthalmol. 2021 Sep;99(6):637-643. doi: 10.1111/aos.14699. Epub 2021 Feb 24.
To investigate the role of complete blood cell count (CBC) measures in retinal artery occlusion (RAO).
This was a case-control study, including 73 newly diagnosed RAO patients and 73 sex- and age-matched subjects without RAO. On the same day of RAO diagnosis, a blood sample was collected and CBC was determined using an automatic blood counter. Dimensional CBC indices, such as mean platelet volume (MPV) and red cell distribution width (RDW), and some CBC-combined indices, including neutrophil/lymphocyte ratio (NLR), derived NLR [dNLR = neutrophils/(white blood cells - neutrophils)] and platelet/lymphocyte ratio (PLR), were evaluated. Erythrocyte sedimentation rate (ESR) was also measured.
Median neutrophils, red cell distribution width (RDW), NLR and dNLR were 4.5x10 /L (IQR = 3.8-5.8), 13.4% (IQR = 12.7-14.75), 2.47 (IQR = 1.85-3.13) and 1.70 (IQR = 1.26-2.18) in RAO patients and 4x10 /L (IQR = 3.18-4.93), 12.9% (IQR = 12-14), 1.86 (IQR = 1.42-2.44) and 1.32 (IQR = 1.02-1.64) in controls. RAO patients had significantly higher values of neutrophils (p = 0.003), RDW (p = 0.0011), NLR (p = 0.0001) and dNLR (p = 0.0001). There were no significant differences between the values of white blood cells, lymphocytes, platelet count, MPV and PLR. Multivariate logistic regression models revealed a statistically significant correlation between RAO and increased RDW (OR = 1.36, 95% CI = 1.06-1.73, p = 0.015), NLR (OR = 2.02, 95% CI = 1.34-3.06, p = 0.0009) and dNLR (OR = 3.4, 95% CI = 1.71-6.75, p = 0.0005).
Results suggest that RDW, NLR and dNLR may be involved in the pathogenesis of RAO and predict its occurrence. However, high-quality epidemiologic studies, preferably of cohort design, are warranted to confirm whether, or not, an RDW, NLR and dNLR may be considered potential biomarkers of RAO.
探讨全血细胞计数（CBC）指标在视网膜动脉阻塞（RAO）中的作用。
这是一项病例对照研究，纳入73例新诊断的RAO患者和73例年龄及性别匹配的非RAO受试者。在RAO诊断当天采集血样，使用自动血液计数器测定CBC。评估了CBC的维度指标，如平均血小板体积（MPV）和红细胞分布宽度（RDW），以及一些CBC组合指标，包括中性粒细胞/淋巴细胞比值（NLR）、衍生NLR [dNLR = 中性粒细胞/（白细胞 - 中性粒细胞）]和血小板/淋巴细胞比值（PLR）。还测量了红细胞沉降率（ESR）。
RAO患者的中性粒细胞、红细胞分布宽度（RDW）、NLR和dNLR中位数分别为4.5×10⁹/L（四分位间距[IQR]=3.8 - 5.8）、13.4%（IQR = 12.7 - 14.75）、2.47（IQR = 1.85 - 3.13）和1.70（IQR = 1.26 - 2.18），对照组分别为4×10⁹/L（IQR = 3.18 - 4.93）、12.9%（IQR = 12 - 14）、1.86（IQR = 1.42 - 2.44）和1.32（IQR = 1.02 - 1.64）。RAO患者的中性粒细胞（p = 0.003）、RDW（p = 0.0011）、NLR（p = 0.0001）和dNLR（p = 0.0001）值显著更高。白细胞、淋巴细胞、血小板计数、MPV和PLR值之间无显著差异。多因素逻辑回归模型显示，RAO与RDW升高（比值比[OR]=1.36，95%置信区间[CI]=1.06 - 1.73，p = 0.015）、NLR（OR = 2.
