血红蛋白水平与 COVID-19 患者住院死亡率的 U 型关联。
U shape association of hemoglobin level with in-hospital mortality for COVID-19 patients.
机构信息
Department of Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, First Avenue, 16th street, New York, NY, 10003, USA.
Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
出版信息
J Thromb Thrombolysis. 2022 Jan;53(1):113-117. doi: 10.1007/s11239-021-02516-1. Epub 2021 Jul 2.
Our hypothesis was that high hemoglobin (Hb) level might be associated with hypercoagulable state and death due to COVID-19. Of the 9467 hospitalized COVID-19 patients, patients were subdivided into 5 groups based on the level of Hb; Hb < 10 g/dL, 10 g/dL ≤ Hb < 12 g/dL, 12 g/dL ≤ Hb < 14 g/dL, 14 g/dL ≤ Hb < 16 g/dL, and Hb ≥ 16 g/dL. Compared to patients with 12 g/dL ≤ Hb < 14 g/dL, patients with Hb ≥ 16 g/dL had significantly higher adjusted in-hospital mortality (OR [95% CI] 1.62 [1.15-2.27], P = 0.005).
我们的假设是，高血红蛋白（Hb）水平可能与 COVID-19 导致的高凝状态和死亡有关。在 9467 名住院 COVID-19 患者中，根据 Hb 水平将患者分为 5 组；Hb<10 g/dL、10 g/dL≤Hb<12 g/dL、12 g/dL≤Hb<14 g/dL、14 g/dL≤Hb<16 g/dL 和 Hb≥16 g/dL。与 12 g/dL≤Hb<14 g/dL 的患者相比，Hb≥16 g/dL 的患者的住院死亡率显著更高（调整后比值比[95%CI] 1.62 [1.15-2.27]，P=0.005）。
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