肠道微生物群在急性胰腺炎中的改变及相关治疗策略。
Alteration of gut microbiota in acute pancreatitis and associated therapeutic strategies.
机构信息
Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai 201600, China; Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 201600, China.
Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 201600, China.
出版信息
Biomed Pharmacother. 2021 Sep;141:111850. doi: 10.1016/j.biopha.2021.111850. Epub 2021 Jun 30.
Gut microbiome is considered as a crucial regulator of human health. Alteration of gut microbiome has been reported in acute pancreatitis (AP) and probably contributes to the severity of disease. Explore the precise role of gut microbiome in the pathogenesis of AP could offer new strategies to improve the clinical outcomes of AP. This review summarizes the role of gut microbiome in AP, lists possible mechanisms associated with it and offers an overview of current treatments based on gut microbiome.
肠道微生物组被认为是人类健康的重要调节剂。急性胰腺炎 (AP) 中已报道肠道微生物组发生改变，并且可能导致疾病的严重程度增加。探讨肠道微生物组在 AP 发病机制中的确切作用可能为改善 AP 的临床结局提供新的策略。本文综述了肠道微生物组在 AP 中的作用，列出了与之相关的可能机制，并概述了基于肠道微生物组的当前治疗方法。
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