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传染性单核细胞增多症嗜异性抗体的研究。I. 四种抗体群的分离,其中一种具有淋巴细胞毒性活性。

Studies on the heterophile antibodies of infectious mononucleosis. I. Separation of four antibody populations, one of which contains lymphocytotoxic activity.

作者信息

Langhorne J, Feizi T

出版信息

Clin Exp Immunol. 1977 Dec;30(3):354-63.

Abstract

With the aid of insolubilized immunoadsorbents made with glycoproteins, extracted from cow red blood cells (RBC), and with guinea-pig kidney tissue, heterophile antibody populations of the Paul--Bunnell type and the Forssman type were eluted from infectious mononucleosis sera. Two Paul--Bunnell-type antibody populations were separated on the basis of their affinity for cow RBC antigens. The lymphocytotoxic antibodies in the infectious mononucleosis sera were eluted among the low-affinity Paul--Bunnell antibodies.

摘要

借助由从牛红细胞(RBC)中提取的糖蛋白以及豚鼠肾脏组织制成的不溶性免疫吸附剂,从传染性单核细胞增多症血清中洗脱了保罗 - 邦内尔型和福斯曼型嗜异性抗体群体。根据它们对牛红细胞抗原的亲和力,分离出了两种保罗 - 邦内尔型抗体群体。传染性单核细胞增多症血清中的淋巴细胞毒性抗体在低亲和力的保罗 - 邦内尔抗体中被洗脱出来。

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