可用传染性单核细胞增多症血清通过免疫黏附血凝反应检测牛血清中的嗜异性抗原。

Heterophil antigen in bovine sera detectable by immune adherence hemagglutination with infectious mononucleosis sera.

作者信息

Lennette E T, Henle G, Henle W, Horwitz C A

出版信息

Infect Immun. 1978 Mar;19(3):923-7. doi: 10.1128/iai.19.3.923-927.1978.

DOI:10.1128/iai.19.3.923-927.1978

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422280/

Abstract

Bovine sera for tissue culture use were shown to contain heterophil antigen of the Paul-Bunnell-Davidsohn type by immune adherence hemagglutination tests with sera from patients with infectious mononucleosis. The antibody titers observed were comparable to those determined by two other methods; i.e., the immune adherence hemagglutination test was found to be as specific as the differential absorption test with horse erythrocytes or the ox cell hemolysis assay,but it appeared to be the most sensitive of the three procedures. All 16 individual or pooled bovine serum samples showed Paul-Bunnell-Davidsohn antigen at concentrations varying over a fourfold range. The potential usefulness of the immune adherence hemagglutination test for various Paul-Bunnell-Davidsohn antigen-related problems and implications of the observations are discussed.

摘要

通过对传染性单核细胞增多症患者血清进行免疫粘附血凝试验表明，用于组织培养的牛血清含有保罗 - 邦内尔 - 戴维森氏型嗜异性抗原。观察到的抗体效价与通过其他两种方法测定的效价相当；即，发现免疫粘附血凝试验与用马红细胞进行的鉴别吸收试验或牛细胞溶血试验一样具有特异性，但它似乎是这三种方法中最灵敏的。所有16份单独或混合的牛血清样本均显示出浓度在四倍范围内变化的保罗 - 邦内尔 - 戴维森氏抗原。讨论了免疫粘附血凝试验在各种与保罗 - 邦内尔 - 戴维森氏抗原相关问题上的潜在用途以及这些观察结果的意义。

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