Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Department of Basic Sciences, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran Biomed J. 2021 Jul 1;25(4):226-42. doi: 10.52547/ibj.25.4.226.
Viruses are obligatory intracellular parasites that use cell proteins to take the control of the cell functions in order to accomplish their life cycle. Studying the viral-host interactions would increase our knowledge of the viral biology and mechanisms of pathogenesis. Studies on pathogenesis mechanisms of lyssaviruses, which are the causative agents of rabies, have revealed some important host protein partners for viral proteins, especially for most studied species, i.e. Rabies virus. In this review article, the key physical lyssavirus-host protein interactions, their contributions to rabies infection, and their exploitation are discussed to improve the knowledge about rabies pathogenesis.
病毒是专性细胞内寄生虫，它们利用细胞蛋白来控制细胞功能，以完成其生命周期。研究病毒-宿主相互作用将增加我们对病毒生物学和发病机制的了解。对狂犬病病原体——狂犬病毒的发病机制的研究揭示了一些重要的宿主蛋白与病毒蛋白的相互作用，特别是对大多数研究物种而言。在这篇综述文章中，讨论了关键的物理性狂犬病毒-宿主蛋白相互作用、它们对狂犬病感染的贡献以及它们的利用，以提高对狂犬病发病机制的认识。
