Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, Thailand; Department of Rehabilitation Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Obes Res Clin Pract. 2021 Jul-Aug;15(4):315-326. doi: 10.1016/j.orcp.2021.06.009. Epub 2021 Jul 1.
Spermidine is a natural polyamine existing in all living cells known to play an important role in cellular functions. Recently, several studies have reported the effect of alterations in the spermidine pool on metabolic pathways. It has been shown that activation of spermidine/spermine N-1-acetyl-transferase (SSAT), the rate-limiting enzyme in polyamine catabolism, improved glucose and lipid metabolism. In addition, spermidine supplementation has been shown to protect against diet-induced obesity in animal models. However, some clinical studies demonstrated that polyamine levels are increased in childhood obesity and metabolic syndrome patients with type 2 diabetes (T2DM), while polyamine-rich food is associated with a lower incidence of cardiovascular disease (CVD). Therefore, this review aims to summarize and discuss the evidence from in vitro, in vivo and clinical studies on the possible roles of spermidine on metabolic pathways under physiological and obese conditions. All consistent and inconsistent findings are discussed and further studies aiming to fill any gaps in the knowledge are proposed.
精胺是一种天然多胺，存在于所有已知在细胞功能中发挥重要作用的活细胞中。最近，几项研究报告了精胺池的变化对代谢途径的影响。已经表明，激活多胺分解代谢的限速酶精脒/精胺 N-1-乙酰转移酶 (SSAT)，可改善葡萄糖和脂质代谢。此外，精胺补充已被证明可预防动物模型中的饮食诱导肥胖。然而，一些临床研究表明，在肥胖症和 2 型糖尿病 (T2DM) 代谢综合征患者中，多胺水平升高，而富含多胺的食物与心血管疾病 (CVD) 的发病率较低有关。因此，本综述旨在总结和讨论在生理和肥胖条件下，关于精胺对代谢途径可能作用的体外、体内和临床研究的证据。讨论了所有一致和不一致的发现，并提出了旨在填补知识空白的进一步研究。
