School of Life Sciences and Medicine, Shandong University of Technology, Zibo, Shandong, China.
National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China.
Front Immunol. 2023 May 16;14:1156471. doi: 10.3389/fimmu.2023.1156471. eCollection 2023.
Obesity is strongly associated with the occurrence and development of many types of cancers. Patients with obesity and cancer present with features of a disordered gut microbiota and metabolism, which may inhibit the physiological immune response to tumors and possibly damage immune cells in the tumor microenvironment. In recent years, bariatric surgery has become increasingly common and is recognized as an effective strategy for long-term weight loss; furthermore, bariatric surgery can induce favorable changes in the gut microbiota. Some studies have found that microbial metabolites, such as short-chain fatty acids (SCFAs), inosine bile acids and spermidine, play an important role in anticancer immunity. In this review, we describe the changes in microbial metabolites initiated by bariatric surgery and discuss the effects of these metabolites on anticancer immunity. This review attempts to clarify the relationship between alterations in microbial metabolites due to bariatric surgery and the effectiveness of cancer treatment. Furthermore, this review seeks to provide strategies for the development of microbial metabolites mimicking the benefits of bariatric surgery with the aim of improving therapeutic outcomes in cancer patients who have not received bariatric surgery.
肥胖与多种癌症的发生和发展密切相关。肥胖合并癌症患者表现出肠道微生物群和代谢紊乱的特征，这可能会抑制对肿瘤的生理性免疫应答，并可能损害肿瘤微环境中的免疫细胞。近年来，减重手术越来越普遍，被认为是长期减肥的有效策略；此外，减重手术可诱导肠道微生物群发生有利变化。一些研究发现，微生物代谢物，如短链脂肪酸（SCFAs）、胆酸和亚精胺，在抗肿瘤免疫中发挥重要作用。本综述描述了减重手术引起的微生物代谢物的变化，并讨论了这些代谢物对抗肿瘤免疫的影响。本综述旨在阐明减重手术引起的微生物代谢物改变与癌症治疗效果之间的关系。此外，本综述还旨在为开发模仿减重手术益处的微生物代谢物提供策略，以期改善未接受减重手术的癌症患者的治疗效果。
